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The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes.
Front Bioeng Biotechnol
January 2025
Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
This study investigates the mechanical properties as well as and cyto- and biocompatibility of collagen membranes cross-linked with glutaraldehyde (GA), proanthocyanidins (PC), hexamethylendiisocyanate (HMDI) and 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EC/NHS). A non-crosslinked membrane was used as reference control (RF). The initial cytotoxic analyses revealed that the PC, EC, and HMDI crosslinked membranes were cytocompatible, while the GA crosslinked membrane was cytotoxic and thus selected as positive control in the further study.
View Article and Find Full Text PDFInguinal hernia mesh infections: Chronic challenges, atypical pathogens and lessons in sterilisation.
Trop Doct
January 2025
Junior Resident, Department of General Medicine, Silchar Medical College and Hospital, Assam, India.
Chronic mesh infections after inguinal hernia repair present significant clinical challenges due to biofilm-mediated resistance, involvement of multidrug-resistant and atypical pathogens, and gaps in preventive strategies. Our case series of four patients highlights critical research gaps, including the overlooked role of atypical pathogens such as , diagnostic challenges in detecting slow-growing or resistant organisms and perioperative sterilisation lapses, especially inconsistent Glutaraldehyde use during late-day operations. Many patients suffered with persistent sinuses and recurrent hernias months after surgery.
View Article and Find Full Text PDFFormalin and 2.5% Glutaraldehyde/2% Paraformaldehyde in 0.1 M Cacodylate Buffer Inactivation Protocols to Ensure the Proper Fixation of Positive Sense RNA Viruses and Genomic Material Prior to Removal from Containment.
Methods Protoc
December 2024
Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD 21702, USA.
Recommendations released by the CDC in 2023 address the need to demonstrate that the RNA genome of positive-strand RNA viruses is inactivated in addition to viral particles. This recommendation is in response to the similarities between host mRNA and the viral genome that allow the viral RNA to be used as a template by host replication mechanisms to produce infectious viruses; therefore, there is concern that through artificial introduction into host cells, active positive-strand RNA genomes can be utilized to produce infectious viruses out of a containment facility. Utilizing 10% formalin for 7 days or 2.
View Article and Find Full Text PDFHybrid Chitosan Biosorbents: Tunable Adsorption at Surface and Micropore Domains.
Biomimetics (Basel)
November 2024
Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
Herein, we report a study that provides new insight on the knowledge gaps that relate to the role of biopolymer structure and adsorption properties for chitosan adsorbents that are cross-linked with glutaraldehyde. The systematic modification of chitosan cross-linked with glutaraldehyde (CG) and its quaternized forms (QCG) was studied in relation to the reaction conditions: mole ratios of reactants and pH conditions. Complementary adsorbent characterization employed C NMR/FTIR spectroscopy, TGA and DSC, point-zero-charge (PZC), solvent swelling, and sorption studies using selected dye probes.
View Article and Find Full Text PDFDevelopment of Variable Charge Cationic Hydrogel Particles with Potential Application in the Removal of Amoxicillin and Sulfamethoxazole from Water.
Gels
November 2024
Departamento de Polímeros, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 3349001, Chile.
Cationic hydrogel particles (CHPs) crosslinked with glutaraldehyde were synthesized and characterized to evaluate their removal capacity for two globally consumed antibiotics: amoxicillin and sulfamethoxazole. The obtained material was characterized by FTIR, SEM, and TGA, confirming effective crosslinking. The optimal working pH was determined to be 6.
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