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Elucidation of cytotoxicity of α-Synuclein fibrils on immune cells.
Biochim Biophys Acta Proteins Proteom
December 2024
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States; Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, United States. Electronic address:
Progressive aggregation of α-synuclein (α-Syn), a small cytosolic protein involved in cell vesicle trafficking, in the midbrain, hypothalamus, and thalamus is linked to Parkinson's disease (PD). Amyloid oligomers and fibrils formed as a result of such aggregation are highly toxic to neurons. However, it remains unclear whether amyloid-induced toxicity of neurons is the primary mechanism of the progressive neurodegeneration observed upon PD.
View Article and Find Full Text PDFEvidence for the contribution of vasopressin V1 receptors in the pathophysiology of depression.
Biochem Pharmacol
January 2025
Department of Trauma Center, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China. Electronic address:
Depression is a chronic and recurrent psychiatric condition characterised by depressed mood, loss of interest or pleasure, poor sleep, low appetite, and poor concentration. Research has shown that both heritable and environmental risk factors are involved in the pathogenesis of depression. In addition, several studies have indicated that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the development of depression in adulthood.
View Article and Find Full Text PDFCholesterol Accelerates Aggregation of α-Synuclein Simultaneously Increasing the Toxicity of Amyloid Fibrils.
ACS Chem Neurosci
November 2024
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
A hallmark of Parkinson disease (PD) is a progressive degeneration of neurons in the substantia nigra pars compacta, hypothalamus, and thalamus. Although the exact etiology of irreversible neuronal degeneration is unclear, a growing body of experimental evidence indicates that PD could be triggered by the abrupt aggregation of α-synuclein (α-Syn), a small membrane protein that is responsible for cell vesicle trafficking. Phospholipids uniquely alter the rate of α-Syn aggregation and, consequently, change the cytotoxicity of α-Syn oligomers and fibrils.
View Article and Find Full Text PDFChemical composition alterations in rat brain hypothalamus induced by irisin administration using spectroscopic and machine learning techniques.
Anal Biochem
January 2025
Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, 20-093, Poland; Institute of Nuclear Physics, PAS, 31342, Krakow, Poland. Electronic address:
This study employed Fourier transform infrared (FTIR) spectroscopy to determine the chemical composition of brain tissues and the changes induced by irisin at doses of 50 mg and 100 mg. Brain tissues were collected from control rats and those administered with irisin, and key vibrational peaks were analyzed. In the 50 mg irisin group, all described vibrations decreased compared to control tissues, while the 100 mg group showed a decrease only in lipid vibrations.
View Article and Find Full Text PDFQingfei Zhisou oral liquid alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression.
J Tradit Chin Med
October 2024
Institute of Basic Medical Sciences, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
Article Synopsis
- The study investigates the effects of Qingfei Zhisou (QFZS) oral liquid on body temperature regulation and inflammatory factors in rats induced with fever.
- Researchers established a fever model using dry yeast and divided rats into different treatment groups to assess QFZS's impact on body temperature and inflammatory proteins.
- Results indicated that QFZS effectively lowered body temperature and reduced levels of inflammatory markers, suggesting its anti-inflammatory and anti-pyrexia actions may involve the metabolism of specific lipids and regulation of ion channels related to inflammation.
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