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A re-activation model for Yb intensity modulated brachytherapy sources accounting for spatiotemporal isotopic composition.
Med Phys
May 2024
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Background: Intensity modulated brachytherapy based on partially shielded intracavitary and interstitial applicators is possible with a cost-effective Yb production method. Yb is a traditionally expensive isotope suitable for this purpose, with an average γ-ray energy of 93 keV. Re-activating a single Yb source multiple times in a nuclear reactor between clinical uses was shown to theoretically reduce cost by approximately 75% relative to conventional single-activation sources.
View Article and Find Full Text PDFVerification of dose distribution in high dose-rate brachytherapy for cervical cancer using a normoxic N-vinylpyrrolidone polymer gel dosimeter.
J Radiat Res
December 2022
Faculty of Health Sciences, Hiroshima International University, 555-36 Kurosegakuendai, Higashihiroshima, Hiroshima, 739-2695, Japan.
The polymer gel dosimeter has been proposed for use as a 3D dosimeter for complex dose distribution measurement of high dose-rate (HDR) brachytherapy. However, various shapes of catheter/applicator for sealed radioactive source transport used in clinical cases must be placed in the gel sample. The absorbed dose readout for the magnetic resonance (MR)-based polymer gel dosimeters requires calibration data for the dose-transverse relaxation rate (R2) response.
View Article and Find Full Text PDFImplications of applicators orientations on bladder, and rectal doses in gynecological mHDR brachytherapy: A retrospective analysis of reproducibility in multi-fractionated regimen.
J Cancer Res Ther
May 2020
Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Introduction: Variation of doses due to positional uncertainties of applicators based on orthogonal radiograph has been evaluated by several researchers. The present study has analyzed the various possibilities of special alterations of applicator placements in intracavitary brachytherapy (ICBT) and its impact on the dose to target volume, rectum, and bladder. An innovative approach has been suggested to quantify and utilize the special coordinates for reproducibility of applicator based on the pelvic bone landmark.
View Article and Find Full Text PDFIntraoperative delivery of cell-killing boost radiation - a review of current and future methods.
Minim Invasive Ther Allied Technol
August 2016
a Institute for Medical Systems , Otto-von-Guericke University Magdeburg, Magdeburg , Germany.
Techniques for intraoperative radiation therapy (IORT), the applications of tumor bed radiation immediately after surgery or utilising intracavitary access, have evolved in recent years. They are designed to substitute or complement conventional external beam radiation therapy in selected patients. IORT has become an excellent treatment option because of good long-term therapy outcomes.
View Article and Find Full Text PDFLocalizing intracavitary brachytherapy applicators from cone-beam CT x-ray projections via a novel iterative forward projection matching algorithm.
Med Phys
February 2011
Department of Radiation Oncology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
Purpose: To present a novel method for reconstructing the 3D pose (position and orientation) of radio-opaque applicators of known but arbitrary shape from a small set of 2D x-ray projections in support of intraoperative brachytherapy planning.
Methods: The generalized iterative forward projection matching (gIFPM) algorithm finds the six degree-of-freedom pose of an arbitrary rigid object by minimizing the sum-of-squared-intensity differences (SSQD) between the computed and experimentally acquired autosegmented projection of the objects. Starting with an initial estimate of the object's pose, gIFPM iteratively refines the pose parameters (3D position and three Euler angles) until the SSQD converges.
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