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Refining within-subject biological variation estimation using routine laboratory data: practical applications of the refineR algorithm.
Clin Chem Lab Med
December 2024
Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Laboratory Medicine and Pathology, 60498 Haukeland University Hospital, Bergen, Norway.
Spatial correspondence of cortical activity measured with whole head fNIRS and fMRI: Toward clinical use within subject.
Neuroimage
April 2024
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Neurology, Children's Wisconsin, Milwaukee, WI, USA.
Functional near infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) both measure the hemodynamic response, and so both imaging modalities are expected to have a strong correspondence in regions of cortex adjacent to the scalp. To assess whether fNIRS can be used clinically in a manner similar to fMRI, 22 healthy adult participants underwent same-day fMRI and whole-head fNIRS testing while they performed separate motor (finger tapping) and visual (flashing checkerboard) tasks. Analyses were conducted within and across subjects for each imaging approach, and regions of significant task-related activity were compared on the cortical surface.
View Article and Find Full Text PDFIdentifying canonical and replicable multi-scale intrinsic connectivity networks in 100k+ resting-state fMRI datasets.
Hum Brain Mapp
December 2023
Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, Georgia, USA.
Despite the known benefits of data-driven approaches, the lack of approaches for identifying functional neuroimaging patterns that capture both individual variations and inter-subject correspondence limits the clinical utility of rsfMRI and its application to single-subject analyses. Here, using rsfMRI data from over 100k individuals across private and public datasets, we identify replicable multi-spatial-scale canonical intrinsic connectivity network (ICN) templates via the use of multi-model-order independent component analysis (ICA). We also study the feasibility of estimating subject-specific ICNs via spatially constrained ICA.
View Article and Find Full Text PDFA small clinical trial of vaporized cannabis for PTSD: suggestive results and directions for future study.
Trials
September 2023
, Tilray, Nanaimo, BC, Canada.
The last few decades have seen increasing interest in the use of cannabis for post-traumatic stress disorder (PTSD). Recent attempts to evaluate the clinical efficacy of cannabis for PTSD were inconclusive and generalizability was limited by undesirable features of the study drug. The present clinical trial evaluated the effects of a commercially available chemovar that was delivered by vaporization.
View Article and Find Full Text PDFWeek-to-week within-subject and between-subject biological variation of copeptin.
Clin Chem Lab Med
January 2024
Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
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