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Peripheral modulation of pain in conscious guinea pigs: effect of morphine, nalorphine and clonidine.
Braz J Med Biol Res
April 1989
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
1. Morphine and nalorphine were shown to have a peripheral analgesic effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. Naloxone antagonized the effect of morphine and nalorphine.
View Article and Find Full Text PDFQuantum chemical calculations including extensive conformational variations are performed on three morphine-like analgesics with varying N-substituents using the PCILO and INDO methods. The three compounds, morphine, nalorphine, and N-phenethylmorphine, have been shown experimentally to exemplify opiate narcotic agonism, antagonism, and increased agonism, respectively. In this study, these properties are correlated with the electronic and conformational results.
View Article and Find Full Text PDFA comparison of the antinociceptive actions of cholinomimetic and morphine-like drugs.
Br J Pharmacol
September 1970
1. The antinociceptive activity of morphine, nalorphine, oxotremorine and eserine has been examined in mice in electroshock and phenylbenzoquinone writhing tests.2.
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