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Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor.
Front Psychiatry
January 2022
Program in Neuroscience, Department of Psychology, Davidson College, Davidson, NC, United States.
Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate the behavioral effects of stimulants; however, less is known regarding the interactions between stimulants and opioids possessing low to intermediate efficacy at the mu receptor. The purpose of this study was to examine the role of an opioid's relative efficacy at the mu receptor in altering the behavioral effects of dextro(-)amphetamine.
View Article and Find Full Text PDFAcute experiments on 75 adult rabbits were made to study action of intravenous injections of naloxone (0.1 mg/kg), nalorphine (0.5 and 2.
View Article and Find Full Text PDFSocial and environmental enrichment enhances sensitivity to the effects of kappa opioids: studies on antinociception, diuresis and conditioned place preference.
Pharmacol Biochem Behav
August 2003
Department of Psychology, Davidson College, Davidson NC 28035, USA.
Previous studies have reported that social and environmental enrichment can have a marked impact on the functional maturation of the central nervous system and may influence an organism's sensitivity to psychotropic drugs. The purpose of the present study was to examine the effects of social and environmental enrichment on sensitivity to drugs possessing activity at the kappa opioid receptor. Rats were obtained at weaning and randomly assigned to one of two housing conditions: isolated rats were housed individually with no visual or tactile contact with other rats; enriched rats were housed in groups of four in large cages and given various novel objects on a regular basis.
View Article and Find Full Text PDFInteractions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor.
Psychopharmacology (Berl)
May 2003
Department of Psychology, Davidson College, NC 28035-7037, USA.
Rationale: Cocaine and mu opioid agonists increase central dopamine concentrations and produce robust interactions at both neurochemical and behavioral levels. Although the interactions between cocaine and high-efficacy mu opioids have been well characterized, the interactions between cocaine and lower efficacy opioids have not been as extensively examined.
Objective: The purpose of this study was to examine the interactions between cocaine and opioids possessing a range of relative efficacy at the mu receptor.
Sex and rat strain determine sensitivity to kappa opioid-induced antinociception.
Psychopharmacology (Berl)
March 2002
Department of Psychology, University of North Carolina at Chapel Hill, 27599-3270, USA.
Rationale: Recent studies indicate that sex and rodent strain are determinants of sensitivity to opioid-induced antinociception.
Objectives: The present study examined the influence of sex and rat strain on kappa opioid-induced antinociception using a series of kappa opioids that vary in their relative effectiveness.
Methods: In a warm-water (50, 52 and 55C) tail-withdrawal procedure, the antinociceptive effects of kappa opioids were determined in male and female rats of the F344, Lewis and Sprague-Dawley (SD) strains.
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