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Cytotoxic and antibacterial activity of naturally occurring agglutinin produced from the root of Poir.
Nat Prod Res
January 2025
Bioprocess Engineering Division, Smykon Biotech, Kanniyakumari, Tamilnadu, India.
Lectins are naturally occurring agglutinins which are produced more from plants sources compared to animal sources. The present study aims to screen the potential applications of lectin isolated from the mangrove plant, Poir. This root agglutinin of showed highest HA titre with buffalo erythrocytes.
View Article and Find Full Text PDFMonovalent and Divalent Designs of Copper Radiotheranostics Targeting Fibroblast Activation Protein in Cancer.
Cancers (Basel)
December 2024
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
: Fibroblast activation protein (FAP)-targeted theranostic radiopharmaceuticals have shown desired tumor-to-background organ selectivity due to the ubiquitous presence of FAP within the tumor microenvironment. However, suboptimal tumor retention and fast clearance have hindered their use to deliver effective cancer therapies. With well-documented FAP-targeting moieties and linkers appending them to optimal chelators, the development of copper radiopharmaceuticals has attracted considerable interest, given the fact that an ideal theranostic pair of copper radionuclides (Cu: t = 12.
View Article and Find Full Text PDFDiverse plant RNAs coat leaves and are distinct from apoplastic RNAs.
Proc Natl Acad Sci U S A
January 2025
Department of Biology, Indiana University, Bloomington, IN 47405.
Article Synopsis
- Transgenic plants can express double-stranded RNA that silences mRNAs in fungal pathogens, but how this RNA crosses cell membranes during infection is unclear.
- A new protocol allowed researchers to isolate RNA from the leaf surface, revealing a unique pattern distinct from intercellular RNA, suggesting it might be secreted directly rather than through stomata.
- The isolated surface RNAs, primarily from Arabidopsis and including various RNA types, may play a vital role in establishing microbial communities on leaf surfaces.
Designing mimosine-containing peptides as efficient metal chelators: Insights from molecular dynamics and quantum calculations.
J Inorg Biochem
March 2025
Faculty of Chemistry (UPV/EHU), Manuel Lardizabal 3, Donostia-San Sebastian 20018, Spain; DIPC, Manuel Lardizabal 4, Donostia-San Sebastian 20018, Spain. Electronic address:
Mimosine, a non-essential amino acid derived from plants, has a strong affinity for binding divalent and trivalent metal cations, including Zn, Ni, Fe, and Al. This ability endows mimosine with significant antimicrobial and anti-cancer properties, making it a promising candidate for therapeutic applications. Previous research has demonstrated the effectiveness of mimosine-containing peptides as metal chelators, offering a safer alternative to conventional chelation agents.
View Article and Find Full Text PDFThe Role of Metal Tolerance Proteins (MTPs) Associated with the Homeostasis of Divalent Mineral Elements in Ga-Treated Rice Plants.
Toxics
November 2024
College of Environmental Science & Engineering, Guilin University of Technology, Guilin 541004, China.
Mineral elements typically act as transported substrates for metal tolerance proteins (MTPs). The chelation of MTPs with heavy metal ions is a suggestive detoxification pathway in plants; therefore, the trade-off between transporting mineral elements and chelating excess toxic metal ions is inevitable. Gallium (Ga) is an emerging pollutant associated with high-tech industries.
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