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Protective effect of trehalose on sperm chromatin condensation failure and semen quality decline in BDE-209-exposed mice.
Food Chem Toxicol
December 2024
Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, Hefei, 230032, China. Electronic address:
Article Synopsis
- BDE-209 exposure leads to male reproductive toxicity characterized by a decline in sperm quality, but the impact of autophagy in this process was not well understood.
- The study evaluated the protective effects of trehalose (Tre), an autophagy inducer, on reproductive damage during sperm development (spermiogenesis) caused by BDE-209 using a mouse model.
- Results showed that Tre improved various sperm qualities and reduced testicular damage, likely by restoring normal autophagy pathways via AMPK-ULK1 signaling, highlighting potential therapeutic targets for addressing male reproductive toxicity.
Functionally distinct anticoagulant mechanisms of endothelial cells.
Thromb Res
December 2024
Synapse Research Institute Maastricht, Kon. Emmaplein 7, 6217, KD, Maastricht, the Netherlands.
Antithrombin and tissue factor pathway inhibitor (TFPI) provide different anticoagulant mechanisms. Having established a potent anticoagulant role of cultured human umbilical vein endothelial cells in vessel-on-a-chip microfluidic models, we now investigated how these cells modulated thrombin generation under stasis through antithrombin and TFPI pathways. We observed that endothelial monolayers in 96 well-plates strongly delayed and suppressed the thrombin generation process induced by tissue factor, regardless of the presence of whole blood, platelet-rich plasma or platelet-free plasma.
View Article and Find Full Text PDF"Rich arginine and strong positive charge" antimicrobial protein protamine: From its action on cell membranes to inhibition of bacterial vital functions.
Biochim Biophys Acta Biomembr
June 2024
Graduate School of Science and Technology, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki 214-8571, Kanagawa, Japan. Electronic address:
Protamine, an antimicrobial protein derived from salmon sperm with a molecular weight of approximately 5 kDa, is composed of 60-70 % arginine and is a highly charged protein. Here, we investigated the mechanism of antimicrobial action of protamine against Cutibacterium acnes (C. acnes) focusing on its rich arginine content and strong positive charge.
View Article and Find Full Text PDFMelatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT.
PLoS One
March 2024
Department of Urology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Background: Melatonin (MEL) is an indole amine molecule primarily produced in the pineal gland. Melatonin has been shown in numerous studies to have antifibrotic effects on the kidney, liver, and other organs. However, it is still unclear how melatonin works in bladder fibrosis.
View Article and Find Full Text PDFEffect of preoperative ivabradine on hemodynamics during elective off-pump CABG.
Ann Card Anaesth
November 2023
Department of Cardiothoracic Surgery, G B Pant Institute of Postgraduate Medical Education and Research, J L Nehru Marg, New Delhi, India.
Background: Ivabradine is a specific heart rate (HR)-lowering agent which blocks the cardiac pacemaker I channels. It reduces the HR without causing a negative inotropic or lusitropic effect, thus preserving ventricular contractility. The authors hypothesized that its usefulness in lowering HR can be utilized in patients undergoing off-pump coronary artery bypass (OPCAB) surgery.
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