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[The efficacy and tolerability of tolperisone hydrochloride various regimens in the treatment of patients with acute musculoskeletal low back pain].
Zh Nevrol Psikhiatr Im S S Korsakova
October 2024
Clinical Hospital of St. Luka, St-Petersburg, Russia.
Article Synopsis
- The study aimed to evaluate how effective and tolerable different regimens of tolperisone hydrochloride (TH) are for treating acute nonspecific lower back pain (ALBP).
- 90 patients were divided into two groups: one received TH in sustained release form with basic treatment, while the other received TH intramuscularly for 5 days followed by sustained release, with the study lasting 30 days.
- Results showed that group 2 had better pain control for moderate and severe pain over 30 days, improved range of motion, and high therapy adherence, with no major side effects reported.
Separation of tolperisone and its degradation products by a dual cyclodextrin capillary electrophoresis system to study their potential role in allergic events.
J Pharm Biomed Anal
January 2025
Department of Pharmacodynamics, Center for Pharmacology and Drug Research & Development, Semmelweis University, 4 Nagyvárad tér, Budapest H-1089, Hungary. Electronic address:
Tolperisone is a centrally acting muscle relaxant that has been used for the treatment of post-stroke spasticity and low back pain. Recently, the safety of tolperisone pharmaceutical products has been reassessed due to growing concerns over allergic adverse events. Reactive degradants of tolperisone may be responsible for these hypersensitivity reactions.
View Article and Find Full Text PDFMetabolomic study on ostracods exposed to environmentally relevant concentrations of five pharmaceuticals selected via a novel approach.
Sci Total Environ
October 2024
Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Medical University of Warsaw, Banacha 1 Str., 02-097 Warszawa, Poland. Electronic address:
Pharmaceuticals (PhACs) are increasingly detected in aquatic ecosystems, yet their effects on biota remain largely unknown. The environmentally relevant concentrations of many PhACs may not result in individual-level responses, like mortality or growth inhibition, traditional toxicity endpoints. However, this doesn't imply the absence of negative effects on biota.
View Article and Find Full Text PDFSymptomatic Cavum Vergae Cyst in a Geriatric Patient: A Report of a Rare Case and Conservative Management Approach.
Cureus
April 2024
Department of Neurology, Military Medical Academy Hisarya, Hisarya, BGR.
Cavum vergae (CV) cysts constitute a small proportion of intracranial cysts, and although generally asymptomatic, there are occasional cases where they might exhibit clinical manifestations. We present a clinical case of a 79-year-old female patient who had a clinical manifestation of headache on the occipital side of the head with irradiation to the shoulder girdle as well as numbness, dizziness, visual impairment, sleep disturbances, and tingling in the hands for three months. Vertigo and rightward staggering had been experienced for two weeks.
View Article and Find Full Text PDFTolperisone hydrochloride improves motor functions in Parkinson's disease via MMP-9 inhibition and by downregulating p38 MAPK and ERK1/2 signaling cascade.
Biomed Pharmacother
May 2024
Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh. Electronic address:
The mitogen-activated protein kinase (MAPK) signaling pathway, particularly the p38 MAPK and ERK1/2, has been implicated in the pathogenesis of Parkinson's disease (PD). Recent studies have shown that MAPK signaling pathway can influence the expression of matrix metalloproteinase 9 (MMP-9), known for its involvement in various physiological and pathological processes, including neurodegenerative diseases. This study explores the modulation of MMP-9 expression via the MAPK/ERK signaling cascade and its potential therapeutic implications in the context of PD-associated motor dysfunction.
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