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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling.
Elife
January 2025
Departments of Molecular & Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, United States.
Wnt/β-catenin signaling directs animal development and tissue renewal in a tightly controlled, cell- and tissue-specific manner. In the mammalian central nervous system, the atypical ligand Norrin controls angiogenesis and maintenance of the blood-brain barrier and blood-retina barrier through the Wnt/β-catenin pathway. Like Wnt, Norrin activates signaling by binding and heterodimerizing the receptors Frizzled (Fzd) and low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6), leading to membrane recruitment of the intracellular transducer Dishevelled (Dvl) and ultimately stabilizing the transcriptional coactivator β-catenin.
View Article and Find Full Text PDFInhibition of Endoplasmic Reticulum Stress Cooperates with SLC7A11 to Promote Disulfidptosis and Suppress Tumor Growth upon Glucose Limitation.
Adv Sci (Weinh)
December 2024
Department of Hepatobiliary Surgery, the First Affiliated Hospital, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Disulfidptosis is a newly discovered type of regulated cell death triggered by disulfide bond accumulation and NADPH (nicotinamide adenine dinucleotide phosphate) depletion due to glucose deprivation. However, the regulatory mechanisms involving additional cellular circuits remain unclear. Excessive disulfide bond accumulation can impair endoplasmic reticulum (ER) homeostasis and activate the ER stress response.
View Article and Find Full Text PDFHarnessing ROS Amplification and GSH Depletion Using a Carrier-Free Nanodrug to Enhance Ferroptosis-Based Cancer Therapy.
Small
December 2024
Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, P. R. China.
Ferroptosis, a non-apoptotic form of cell death characterized by the production of reactive oxygen species (ROS) and massive accumulation of lipid peroxidation (LPO), shows significant promise in cancer therapy. However, the overexpression of glutathione (GSH) at the tumor site and insufficient ROS often result in unsatisfactory therapeutic efficacy. A multistage, GSH-consuming, and ROS-providing carrier-free nanodrug capable of efficiently loading copper ions (Cu), sorafenib (SRF), and chlorogenic acid (CGA) (Cu-CGA-SRF, CCS-NDs) is developed to mediate enhanced ferroptosis therapy.
View Article and Find Full Text PDFHow does the adoption of nutritional plans influence the performance of meat quail during the growth phase in hot environments?
Front Vet Sci
December 2024
Research Group in Bioclimatology, Ethology and Animal Welfare (BioEt), Department of Animal Science, Federal University of Paraiba, Areia, Paraiba, Brazil.
The present study aimed to evaluate the effects of different nutritional plans on meat quails subjected to heat stress. A total of 324 quails male European quails () were used, with an average initial weight of 121.48 g ± 3.
View Article and Find Full Text PDFsp. nov., isolated from the gut of honeybee ().
Int J Syst Evol Microbiol
December 2024
College of Life Sciences, Northeast Agricultural University, Harbin 150030, PR China.
Two novel bifidobacteria (designated F806-1 and F814-1.1) isolated from the gut of honeybee () were characterized in the present study. 16S rRNA gene sequence analysis indicated that strains F806-1 and F814-1.
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