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Vascular risk factors and cerebrovascular pathologic changes on autopsy: The 90+ Study.
Alzheimers Dement
January 2025
Department of Neurology, University of California, Irvine, California, USA.
Introduction: Cerebrovascular pathologic changes (CVPC) are prevalent and associated with dementia in those ≥ 90 years. However, CVPC associations to traditional risk factors (hypertension, diabetes, and hyperlipidemia) are variable. We hypothesized that neither traditional risk factors nor related medications would be associated with CVPC presence.
View Article and Find Full Text PDFRenal microangiopathy induced by lenvatinib in hepatocellular carcinoma: a case report and literature review.
Front Pharmacol
November 2024
Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.
Lenvatinib, a multi-target inhibitor of receptor tyrosine kinases, has been increasingly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its association with renal adverse effects, including proteinuria and renal microvascular complications, was not fully understood in HCC patients. We reported a case of a 68-year-old male with a history of hypertension, diabetes mellitus, and hepatitis C virus (HCV) infection, diagnosed with primary HCC in 2015.
View Article and Find Full Text PDFANCA-associated vasculitis with slowly progressive renal dysfunction: a little-known but treatable disease.
BMJ Case Rep
November 2024
Nephrology and Dialysis, Kantonsspital Baden AG, Baden, Aargau, Switzerland
The clinical spectrum of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) with renal involvement includes forms with a slowly progressive course. These forms are poorly recognised and, therefore, often associated with misdiagnosis and delayed treatment. We present here a case of slowly progressive AAV with renal involvement.
View Article and Find Full Text PDFHypertension may associate with cerebral small vessel disease and infarcts through the pathway of intracranial atherosclerosis.
Neurobiol Aging
January 2025
Division of Geriatrics, University of Sao Paulo Medical School, Sao Paulo 01246-903, Brazil. Electronic address:
Hypertension, a major modifiable risk factor for cardiovascular diseases, is linked to late-life neurocognitive disorders such as vascular dementia and Alzheimer's disease (AD). This study explores the associations between hypertension, intracranial atherosclerotic disease (ICAD), cerebral small vessel disease (cSVD), and Alzheimer's disease neuropathologic change (ADNC) in a large community-based autopsy study. This cross-sectional study used data from the Biobank for Aging Studies of the University of São Paulo Medical School.
View Article and Find Full Text PDFEffect of betablockers on the course of Martorell hypertensive ulcers: a retrospective study.
Acta Derm Venereol
November 2024
Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Martorell hypertensive ulcer (MHU) represents a painful, difficult-to-handle condition associated with peri-pheral, subcutaneous arteriolosclerosis caused by chronic hypertensive disease. Betablockers are effective for and widely used to treat hypertensive disease but are reported to exacerbate peripheral vasoconstriction. The effect of betablockers on pre-existing arteriolosclerosis and the course of MHU is, however, unknown.
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