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Evaluation of the focus reduction neutralization and ELISA tests compared to the plaque reduction neutralization test for the detection of antibodies against measles virus.
Biologicals
November 2024
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Article Synopsis
- Measles, caused by the measles virus, remains a global health challenge despite the availability of an effective vaccine, with a need for better methods to assess community immunity.* -
- The enzyme-linked immunosorbent assay (ELISA) is the standard immunity test but often fails to detect low antibody levels, while the more accurate plaque reduction neutralization test (PRNT) is impractical for regular use.* -
- This study validated the focus reduction neutralization test (FRNT) as a reliable alternative to PRNT, demonstrating that FRNT provides similar sensitivity and perfect correlation in identifying protective antibodies compared to PRNT.*
Differential diagnosis on measles and rubella discarded cases highlights a sharp increase in parvovirus B19 infections in Milan, Northern Italy, in the first months of 2024.
J Med Virol
September 2024
Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
In line with European trends, since 2023 Lombardy (Northern Italy) is experiencing a resurgence of measles and an increased number of reported cases of fever and rash. Measles discarded cases observed in our region within the context of measles and rubella surveillance from the first few months of 2024 (N = 30) were investigated for parvovirus B19 (B19V) and other rash-associated viruses. Thirteen cases tested positive for B19V DNA, representing a significant increase from previous years (on average 3 cases per year, p < 0.
View Article and Find Full Text PDFA Cross-Sectional Study of Measles-Specific Antibody Levels in Australian Blood Donors-Implications for Measles Post-Elimination Countries.
Vaccines (Basel)
July 2024
Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia.
Passive immunisation with normal human immunoglobulin (NHIG) is recommended as post-exposure prophylaxis (PEP) for higher-risk measles contacts where vaccination is contraindicated. However, the concentration of measles-specific antibodies in NHIG depends on antibody levels within pooled donor plasma. There are concerns that measles immunity in the Australian population may be declining over time and that blood donors' levels will progressively decrease, impacting levels required to produce effective NHIG for measles PEP.
View Article and Find Full Text PDFSeroprevalence of measles antibodies in the Italian general population in 2019-2020.
Vaccine
September 2024
National Coordinator of the Working Group "Vaccines and Immunization Policies", Italian Society of Hygiene, Preventive Medicine and Public Health, Italy.
Article Synopsis
- Italy has seen a significant drop in measles cases but hasn't yet eliminated the disease, prompting a study on the prevalence of anti-measles antibodies in various demographics.
- A total of 3746 serum samples from healthy individuals aged 6-64 were analyzed, revealing an overall anti-measles IgG seroprevalence of 91.2%, with higher rates in younger (94.2%) and older (97.6%) age groups.
- There is notable regional variation in seroprevalence, with higher levels in the South (93.2%) compared to Northern-Central Italy (88.9%), highlighting the need for ongoing vaccination efforts to prevent future outbreaks.
Raising Epidemiological Awareness: Assessment of Measles/MMR Susceptibility in Highly Vaccinated Clusters within the Hungarian and Croatian Population-A Sero-Surveillance Analysis.
Vaccines (Basel)
May 2024
Department of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.
Perceptions of the complete eradication of vaccine-preventable diseases such as measles, mumps, and rubella (MMR) may foster complacency and compromise vaccination efforts. Decreased measles vaccination rates during the COVID-19 pandemic have heightened the risk of outbreaks, even in adequately vaccinated populations. To address this, we have aligned with ECDC recommendations, leveraging previous cross-border sero-epidemiological assessments between Pécs, Hungary, and Osijek, Croatia, to identify latent risk groups and uncover potential parallels between our nations.
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