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Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway.
Clin Exp Hypertens
December 2024
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Purpose: Hyperuricemia (HUA) is an important factor leading to chronic kidney disease (CKD). The kidney tubular inflammatory response is activated in HUA. This study aimed to investigate whether lactate dehydrogenase A (LDHA) is involved in mediating uric acid-induced kidney tubular inflammatory response.
View Article and Find Full Text PDFPhotoinduced Copper-Catalyzed Cross-Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay.
Adv Sci (Weinh)
December 2024
State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS, 345 Lingling Road, Shanghai, 200032, P. R. China.
The transition metal-catalyzed direct coupling reactions involving electron-rich Fischer carbene species are largely underdeveloped and remain a big challenge. Here, a direct coupling reaction of azoles and azine N-oxides is reported with Fischer copper carbene species bearing an α-siloxy group i, which can be in situ generated from acylsilanes catalytically under photoirradiation and redox-neutral conditions. This coupling reaction between electron-rich α-siloxy Fischer Cu-carbene species with hard carbanion nucleophiles may undergo a bimetallic relay process, which is confirmed by the kinetic analysis and in situ NMR analysis.
View Article and Find Full Text PDFModulation of cutaneous vasodilation by reactive oxygen species during local and whole body heating in young and older adults.
Am J Physiol Regul Integr Comp Physiol
December 2024
Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
We evaluated reactive oxygen species (ROS) modulation of cutaneous vasodilation during local and whole body passive heating in young and older adults. Cutaneous vascular conductance normalized to maximum vasodilation (%CVC) was assessed in young and older adults (10/group) using laser-Doppler flowmetry at four dorsal forearm sites treated with ) Ringer solution (control), ) 100 µM apocynin (NADPH oxidase inhibitor), ) 10 µM allopurinol (xanthine oxidase inhibitor), or ) 10 µM tempol (superoxide dismutase mimetic), via intradermal microdialysis during local () and whole body heating (). In , forearm skin sites were set at 33°C during baseline and then progressively increased to 39°C and 42°C (30 min each).
View Article and Find Full Text PDFCyclic Nitroxide 4-Methoxy-Tempo May Decrease Serum Amyloid A-Mediated Renal Fibrosis and Reorganise Collagen Networks in Aortic Plaque.
Int J Mol Sci
July 2024
Redox Biology Group, Discipline of Pathology, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Acute-phase serum amyloid A (SAA) can disrupt vascular homeostasis and is elevated in subjects with diabetes, cardiovascular disease, and rheumatoid arthritis. Cyclic nitroxides (e.g.
View Article and Find Full Text PDFRedox Properties of Ferredoxin:NADP Oxidoreductase: Potentiometric Characteristics and Reactions with Pro-Oxidant Xenobiotics.
Int J Mol Sci
May 2024
Department of Xenobiotics Biochemistry, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio Av. 7, LT-10257 Vilnius, Lithuania.
ferredoxin:NADP oxidoreductase (FNR) is a thioredoxin reductase-type FNR whose redox properties and reactivity with nonphysiological electron acceptors have been scarcely characterized. On the basis of redox reactions with 3-acetylpyridine adenine dinucleotide phosphate, the two-electron reduction midpoint potential of the flavin adenine dinucleotide (FAD) cofactor was estimated to be -0.240 V.
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