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Additional benefits of combined ceftriaxone and adipose-derived mesenchymal stem cells on revamping the outcomes in rodent after acute spinal infection.
J Mol Histol
January 2025
Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Dapi Rd. Niaosung Dist, Kaohsiung City, 83301, Taiwan.
Article Synopsis
- The study examined the effects of ceftriaxone and adipose-derived mesenchymal stem cells (ADMSCs) on protecting the spinal cord from acute spinal infection (ASI) in rats.
- Results showed that the combination treatment of ceftriaxone and ADMSCs led to significantly lower inflammatory markers and bacterial counts compared to the individual treatments, indicating better inflammation control and tissue preservation.
- By day 28, the combination therapy demonstrated superior results in protecting vertebral bone and spinal cord integrity compared to each treatment alone, suggesting a potential therapeutic strategy for ASI.
Use of fluoroquinolones and risk of rhegmatogenous retinal detachment: a retrospective cohort study using two nationwide representative claims databases.
Front Pharmacol
December 2024
Division of General Internal Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Background: Although biological plausibility suggests that fluoroquinolones could lead to rhegmatogenous retinal detachment (RRD) through collagen degradation, real-world evidence on their relative risk of RRD is inconsistent, with limited information on absolute risk estimates.
Objective: The study aimed to estimate the RRD risk associated with fluoroquinolones versus other antibiotics with similar indications (i.e.
β-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment.
Front Microbiol
December 2024
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Understanding the impact of antibiotics on bacterial metabolism is crucial for elucidating their mechanisms of action and developing more effective therapeutic strategies. β-lactam antibiotics, distinguished by their distinctive β-lactam ring structure, are widely used as antimicrobial agents. This study investigates the global metabolic alterations induced by three β-lactam antibiotics-meropenem (a carbapenem), ampicillin (a penicillin), and ceftazidime (a cephalosporin)-in .
View Article and Find Full Text PDFResistome phylodynamics of multidrug-resistant isolated from diarrheal patients.
Microbiol Spectr
November 2024
Gut-Brain Axis Laboratory, Infectious Diseases Division (IDD), icddr, b, Dhaka, Bangladesh.
Multi-drug resistance (MDR) in continues to pose a significant public health challenge, particularly in developing countries. Recent advances in genomics strengthen the surveillance of MDR-pathogens and antimicrobial resistance (AMR) mediators. However, genome-based investigations into resistome dynamics in are limited, specifically in Bangladesh.
View Article and Find Full Text PDFComparative validation of UV-spectrophotometry and RP-HPLC methods for cefixime and moxifloxacin analysis.
Anal Biochem
February 2025
School of Pharmacy, RK University, Gujarat, India. Electronic address:
Aim: This study presents the development and validation of UV-spectrophotometry and RP-HPLC methods for the simultaneous quantification of Cefixime Trihydrate (CEFI) and Moxifloxacin Hydrochloride (MOXI) in pharmaceutical formulations.
Methodology: Two UV-spectrophotometric methods, including the absorbance ratio (Q-Absorption) and First Order Derivative Spectroscopy, were developed and validated for their linearity, precision, accuracy, and sensitivity. Additionally, a robust RP-HPLC method using a C18 column and optimized mobile phase was employed for efficient separation and simultaneous estimation of CEFI and MOXI.
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