Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Development and Validation of a Prediction Model Using Sella Magnetic Resonance Imaging-Based Radiomics and Clinical Parameters for the Diagnosis of Growth Hormone Deficiency and Idiopathic Short Stature: Cross-Sectional, Multicenter Study.
J Med Internet Res
November 2024
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background: Growth hormone deficiency (GHD) and idiopathic short stature (ISS) are the major etiologies of short stature in children. For the diagnosis of GHD and ISS, meticulous evaluations are required, including growth hormone provocation tests, which are invasive and burdensome for children. Additionally, sella magnetic resonance imaging (MRI) is necessary for assessing etiologies of GHD, which cannot evaluate hormonal secretion.
View Article and Find Full Text PDFThe Pediatric Growth Hormone Deficiency Patient Journey: Identifying Opportunities for Digital Health Interventions.
Stud Health Technol Inform
November 2024
Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, UK.
Article Synopsis
- * A patient journey map, created from secondary data analysis of interviews with patients and caregivers across multiple European countries, outlines six stages: awareness, diagnosis, treatment planning, initiation, maintenance, and transition.
- * This first comprehensive PGHD patient journey map highlights emotional challenges at each stage and suggests opportunities for improved interventions to enhance patient adherence and overall health outcomes.
The clinical and genetic aspects of six individuals with variants and isolated growth hormone deficiency type II.
Front Endocrinol (Lausanne)
October 2024
Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, Fujian, ;China.
Article Synopsis
- Isolated growth hormone deficiency type II (IGHD II) is a genetic condition leading to low growth hormone production, resulting in stunted growth and lower IGF-1 levels in affected individuals.
- The study examined six children from Chinese families with IGHD II, revealing various genetic variants associated with the condition, including several novel mutations.
- After starting growth hormone replacement therapy, the children showed significant improvement in height, with an average increase of 1.21 SDS in the first six months and 1.79 SDS in the first year of treatment.
Long-term effectiveness and safety of long-acting growth hormone preparation in children with growth hormone deficiency.
J Pediatr Endocrinol Metab
December 2024
Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
Objectives: To evaluate the long-term effectiveness of weekly vs. daily growth hormone (GH) administration in children with GH deficiency.
Methods: This study, part of the "LG Growth Study", included a total of 996 children with GH deficiency (773 receiving daily GH and 193 receiving weekly GH).
Hsa_circ_0002473 inhibits GH3 cell proliferation and GH secretion as a competitive endogenous RNA for has-miR-4645-3p.
J Pediatr Endocrinol Metab
December 2024
Department of Neurology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Growth hormone deficiency (GHD) diagnosis still lacks a gold standard or ideal diagnostic marker. Unlike other epigenetic mechanisms, non-coding RNAs regulate post-transcriptional levels. The information on non-coding RNAs in the field of GHD is limited.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!