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Phenotypic, Metabolic, and Functional Characterization of Experimental Models of Foamy Macrophages: Toward Therapeutic Research in Atherosclerosis.
Int J Mol Sci
September 2024
CRMSB UMR5536, CNRS DR-15, INSB, 33000 Bordeaux, France.
Different types of macrophages (Mφ) are involved in atherogenesis, including inflammatory Mφ and foamy Mφ (FM). Our previous study demonstrated that two-photon excited fluorescence (TPEF) imaging of NADH and FAD autofluorescence (AF) could distinguish experimental models that mimic the different atherosclerotic Mφ types. The present study assessed whether optical differences correlated with phenotypic and functional differences, potentially guiding diagnostic and therapeutic strategies.
View Article and Find Full Text PDFMorphometry of age pigment (lipofuscin) and of ceroid pigment deposits associated with vitamin E deficiency.
Arch Gerontol Geriatr
March 2004
Neurobiology of Aging Centre, N Masera Research Department, INRCA, Via Birarelli 8, I-60121 Ancona, Italy.
Consistent amounts of lipofuscin and of ceroid pigment associated with vitamin E deficiency are reported to represent morphological correlates of aging and increased oxidative stress. A reliable quantification of these yellow autofluorescent deposits is of critical biological significance, thus we carried out a computer-assisted morphometric study on the accumulation of lipofuscin in physiological aging and of ceroid pigment in vitamin E deficiency, respectively. The total area and the size distribution of lipofuscin or ceroid pigment deposits were measured in CA3 hippocampal pyramidal neurons of 6-, 12-, 18- and 25-month-old rats, as well as in vitamin E deficient animals of 18 months of age.
View Article and Find Full Text PDFA critical analysis of the literature of mitochondrial disorders reveals that genetic diseases of oxidative phosphorylation are often associated with impaired beta-oxidation, and vice versa, and preferentially affect brain, retina, heart and skeletal muscle, tissues which depend on docosahexaenoic (22:6n-3)-containing phospholipids for functionality. Evidence suggests that an increased NADH/NAD(+) ratio generated by reduced flux through the respiratory chain inhibits beta-oxidation, producing secondary carnitine deficiency while increasing reactive oxygen species and depleting alpha-tocopherol (alpha-TOC). These events result in impairment of the recently elucidated mitochondrial pathway for synthesis of 22:6n-3-containing phospholipids, since carnitine and alpha-TOC are involved in their biosynthesis.
View Article and Find Full Text PDFEvaluation of the possible role of coenzyme Q10 and vitamin E in juvenile neuronal ceroid-lipofuscinosis (JNCL).
Mol Aspects Med
November 1997
Children's Hospital, University of Helsinki, Finland.
The juvenile type of neuronal ceroid lipofuscinosis (JNCL) is a recessively inherited, progressive neurodegenerative disease. In this study the levels of the antioxidant factors coenzyme Q10 (CoQ10) and vitamin E (alpha-tocopherol) were measured in plasma samples of 29 JNCL patients and compared to 48 healthy controls. A significant reduction of the coenzyme Q10 level (0.
View Article and Find Full Text PDFFeline pansteatitis: a report of five cases.
Acta Vet Scand
September 1996
Djursjukhuset Albano-Animal Hospital of Stockholm, Danderyd, Sweden.
Pansteatitis (yellow fat disease, panniculitis, steatitis) is an inflammatory disease of adipose tissue throughout the body 1987). It was first experimentally induced by in 1946 in cats fed a diet deficient in vita-min E and high in cod liver oil 1946). It has since been reported as a clinical condition by several authors 1953, 1973, 1975, 1982, 1986).
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