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Previous strength training attenuates ouabain-induced bipolar disorder-related behaviors and memory deficits in rats: Involvement of hippocampal ERK/CREB and PI3K/AKT/mTOR pathways.
Neurochem Int
December 2024
Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS, Brazil; Physical Education Undergraduation, Federal University of Pampa, Uruguaiana, RS, Brazil. Electronic address:
Bipolar disorder (BD) is a central nervous system condition that is typified by fluctuations in mood, oscillating between depressive and manic, and/or hypomanic episodes. The objective of this study was to test the hypothesis that strength training may act as a potent protector against behavioral and neurochemical changes induced by BD. A strength training protocol was performed with adult male Wistar rats, and seven days following the conclusion of training, a single ouabain injection was administered.
View Article and Find Full Text PDFMale Wistar Rats Chronically Fed with a High-Fat Diet Develop Inflammatory and Ionic Transport Angiotensin-(3-4)-Sensitive Myocardial Lesions but Preserve Echocardiographic Parameters.
Int J Mol Sci
November 2024
Graduate Program in Translational Biomedicine (BIOTRANS), Grande Rio University (UNIGRANRIO), Duque de Caxias 25071-202, Brazil.
The central aim of this study was to investigate whether male Wistar rats chronically fed a high-fat diet (HFD) over 106 days present high levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and Na and Ca transport alterations in the left ventricle, together with dyslipidemia and decreased glucose tolerance, and to investigate the influence of Ang-(3-4). The rats became moderately overweight with an expansion of visceral adiposity. Na-transporting ATPases, sarco-endoplasmic reticulum Ca-ATPase (SERCA2a), and the abundance of Angiotensin II receptors were studied together with lipid and glycemic profiles from plasma and left-ventricle echocardiographic parameters fractional shortening (FS) and ejection fraction (EF).
View Article and Find Full Text PDFThe cystogenic effects of ouabain in autosomal dominant polycystic kidney disease require cell caveolae.
Exp Cell Res
January 2025
Department of Cell Biology and Physiology and the Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address:
Article Synopsis
- Ouabain, a hormone, speeds up the progression of autosomal dominant polycystic kidney disease (ADPKD) by increasing cyst area and fibrosis specifically in ADPKD mice due to its interaction with Na,K-ATPase (NKA).
- Researchers created a mouse model with a knockout of caveolin-1 (CAV1), the main structural protein of caveolae, to investigate the role of these structures in ouabain's effect on ADPKD.
- The study found that without caveolae, the ADPKD mice did not show increased cyst progression or cellular changes in response to ouabain, indicating that caveolae play a crucial role in NKA signaling and the advancement of
Digoxin and its Na/K-ATPase-targeted actions on cardiovascular diseases and cancer.
Bioorg Med Chem
November 2024
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States. Electronic address:
Na/K-ATPase (NKA) is a plasma membrane ion-transporting protein involved in the generation and maintenance of Na and K gradients across the cell membrane, which can produce a driving force for the secondary transport of metabolic substrates. NKA also regulates intracellular calcium that is responsible for modulating numerous cellular processes, while it interacts with many other proteins and functions as a signal transducer, with several signaling pathways being involved. Thus, NKA has become an important target for the treatment of human diseases.
View Article and Find Full Text PDFInfluence of Intraocular Pressure on the Expression and Activity of Sodium-Potassium Pumps in the Corneal Endothelium.
Int J Mol Sci
September 2024
Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec City, QC G1S 4L8, Canada.
The corneal endothelium is responsible for pumping fluid out of the stroma in order to maintain corneal transparency, which depends in part on the expression and activity of sodium-potassium pumps. In this study, we evaluated how physiologic pressure and flow influence transcription, protein expression, and activity of Na+/K+-ATPase. Native and engineered corneal endothelia were cultured in a bioreactor in the presence of pressure and flow (hydrodynamic culture condition) or in a Petri dish (static culture condition).
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