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New progestogens: a review of their effects in perimenopausal and postmenopausal women.
Drugs Aging
February 2005
Rockefeller University and Population Council, New York, New York, USA.
The progestins have different pharmacological properties depending upon the parent molecule, usually testosterone or progesterone, from which they are derived. Very small structural changes in the parent molecule may induce considerable differences in the activity of the derivative. In postmenopausal women with an intact uterus, progestins are used in combination with estrogen as hormone-replacement therapy (HRT).
View Article and Find Full Text PDFEffects of clomiphene citrate on ovarian function in hypophysectomized rats.
J Reprod Fertil
July 1989
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
On Days 28-30 of age, hypophysectomized rats were treated with oestradiol-17 beta (0.1 mg/day) and/or clomiphene citrate (0.1 mg/day).
View Article and Find Full Text PDFBlockage of ovulation by an angiotensin antagonist.
Science
June 1988
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Angiotensin II (Ang II) is present in high concentrations in preovulatory follicular fluid, and ovarian follicular cells have specific Ang II receptors. To investigate the possible direct involvement of Ang II in ovulation the specific receptor antagonist of Ang II, saralasin, was administered by intraperitoneal injection to immature rats in which follide development and ovulation had been induced with pregnant mare serum gonadotrophin (PMSG) and human chorionic gonadotrophin (hCG), respectively. Saralasin halved the number of oocytes found in the fallopian tubes 17 to 20 hours after administration of hCG.
View Article and Find Full Text PDFHuman chorionic gonadotropin and luteinizing hormone-releasing hormone reverse the blockade of ovulation in pregnant mare's serum gonadotropin-primed immature rats by the anti-androgenic drug, hydroxyflutamide.
Can J Physiol Pharmacol
June 1988
MRC Group in Reproductive Biology, University of Western Ontario, London, Canada.
The present study was designed to examine mechanism(s) of the anti-ovulatory action of the anti-androgen, hydroxyflutamide (OH-F). Prepubertal rats were treated with 4 IU pregnant mare's serum gonadotropin (PMSG) (day -2) to induce first estrus and ovulation. They received OH-F in sesame oil or oil alone at 08:00 and 20:00 h on day 0 (the day of proestrus) and ovulations were assessed on the morning of day 1.
View Article and Find Full Text PDF[Clinical and biological justifications for the use of Triella].
Rev Fr Gynecol Obstet
December 1986
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