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The influenza vaccination's impact elderly's health outcomes in Catalonia (Spain).
Health Policy
January 2025
Secretariat of Public Health, Department of Health, Generalitat de Catalunya, Aragó, 330-332, Barcelona 08009, Spain.
The most effective method of preventing influenza infection and complications is through vaccination. However, annual vaccination rates remain low. This study examines the impact of influenza vaccination on healthcare utilisation among the elderly population in Catalonia, Spain.
View Article and Find Full Text PDFBacterial and Viral Co-Infections in COVID-19 Patients: Etiology and Clinical Impact.
Biomedicines
September 2024
National Laboratory "Influenza and ARD", Department of Virology, National Centre of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
Background: Mixed infections can worsen disease symptoms. This study investigated the impact of mixed infections with viral and bacterial pathogens in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: Using the in-house multiplex PCR method, we tested 337 SARS-CoV-2 positive samples for co-infections with three bacterial and 14 other viral pathogens.
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections.
J Biomed Sci
July 2024
N.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Article Synopsis
- A limited number of innovative antibacterial agents are being developed to effectively target critical Gram-negative bacteria resistant to current treatments, with endolysins showing promise due to their unique action against these pathogens.
- The study uses a multidisciplinary approach including genetic engineering, structural analysis, and various formulations of the engineered endolysin LysECD7-SMAP, which are tested for effectiveness in preclinical models of infections such as sepsis and pneumonia.
- Results indicate that LysECD7-SMAP is effective against multiple drug-resistant bacteria, and in vivo studies confirm the efficacy of its formulated dosage forms, along with insights into how it interacts with bacterial cell walls.
Evaluation of in vitro activity of ceftaroline against pathogens associated with community-acquired pneumonia: ATLAS program 2017-2019.
J Glob Antimicrob Resist
June 2023
Paediatric Clinic, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Objectives: Ceftaroline is an important therapeutic option for community-acquired pneumonia (CAP). Antimicrobial susceptibility to ceftaroline and other antimicrobial agents against Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae isolates collected worldwide from identified respiratory tract sources is reported by age groups (0-18, 19-65, and >65 years).
Methods: Antimicrobial susceptibility of isolates, collected as part of the ATLAS program (2017-2019), was performed per EUCAST/CLSI guidelines.
Low prevalence of influenza viruses and predominance of A(H3N2) virus with respect to SARS-CoV-2 during the 2021-2022 season in Bulgaria.
J Med Virol
February 2023
National Laboratory "Influenza and ARI", Department of Virology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Social distancing, mask-wearing, and travel restrictions during the COVID-19 pandemic have significantly impacted the spread of influenza viruses. The objectives of this study were to analyze the pattern of influenza virus circulation with respect to that of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Bulgaria during the 2021-2022 season and to perform a phylogenetic/molecular analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of representative influenza strains. Influenza infection was confirmed using real-time reverse transcription polymerase chain reaction in 93 (4.
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