Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/1097-0142(1967)20:2<295::aid-cncr2820200217>3.0.co;2-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Case of Clinical Confusion Due to Erroneous M-protein Quantifications: To Splice or Skim?
EJIFCC
December 2022
Division of Hematology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.
An M-protein identified on electrophoresis is conventionally quantified by integrating the M-spike from baseline (PD), invariably including some irrelevant/background proteins. The use of an alternative approach that skims the M-spike tangentially thereby excluding the background proteins (TS), however, has been scanty. We report herein a case in which PD overestimated the M-proteins inconsistently, leading to confusion over relapse in a multiple myeloma patient.
View Article and Find Full Text PDFSynchronous detection of multiple myeloma and acute myeloid leukemia: A diagnostic and therapeutic challenge.
J Oncol Pharm Pract
March 2021
Department of Hematology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
Introduction: Synchronous detection of multiple myeloma and acute myeloid leukemia in a single patient is a rare coincidence. Treatment of these patients is still unclear, mostly based on acute myeloid leukemia strategies combined with bortezomib.
Case Report: A 72-year-old male with no medical history was investigated for pancytopenia.
Plasmablastic light chain myeloma presenting as pancytopenia: An unusual presentation.
Natl Med J India
December 2018
Department of Pathology, Postgraduate Institute of Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi 110001, India.
Light chain myeloma (LCM) is an unusual neoplasm accounting for about 1 8% of all plasma cell myelomas. It is characterized by the absence of a detectable M protein in the serum and urine protein electrophoresis, altered free light chain ratio, bone marrow plasmacytosis and related organ or tissue damage. We report a 60-year-old man with LCM presenting with pancytopenia.
View Article and Find Full Text PDFMonoclonal gammopathy-associated pure red cell aplasia.
Br J Haematol
June 2016
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.
View Article and Find Full Text PDF[Classification, staging and prognostic indices for multiple myeloma].
Nihon Rinsho
December 2007
National Hospital Organization, Nagoya Medical Center.
The monoclonal gammopathies are a group of heterogeneous disorders associated with monoclonal proliferation of plasma cells. The International Myeloma Working Group proposed the new criteria for diagnosis and classification based on routinely available examinations. According to the criteria, symptomatic myeloma requires evidence of an M -protein in serum and urine, bone marrow plasmacytosis and related end -organ damage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!