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Characterization of senescence-associated transcripts in the human placenta.
Placenta
January 2025
Magee-Women's Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:
Introduction: Fusion of mononucleated cytotrophoblasts into syncytium leads to trophoblast senescence. Yet, premature senescence is associated with preeclampsia, fetal growth restriction (FGR), and related obstetrical syndromes. A set of 28 transcripts that comprise senescence-associated secretory phenotype (SASP) was recently described in placentas from women with preeclampsia.
View Article and Find Full Text PDFPro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes.
Mol Hum Reprod
January 2025
Follicle Biology Laboratory, Research Group Genetics, Reproduction and Development, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Biphasic in vitro oocyte maturation (IVM) can be offered as a patient-friendly alternative to conventional ovarian stimulation in in vitro fertilization (IVF) patients predicted to be hyper-responsive to ovarian stimulation. However, cumulative live birth rates after IVM per cycle are lower than after conventional ovarian stimulation for IVF. In different animal species, supplementation of IVM media with oocyte-secreted factors (OSFs) improves oocyte developmental competence through the expression of pro-ovulatory genes in cumulus cells.
View Article and Find Full Text PDFtiRNA-Gln-CTG is Involved in the Regulation of Trophoblast Cell Function in Pre-eclampsia and Serves as a Potent Biomarker.
Front Biosci (Landmark Ed)
January 2025
Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine, Southeast University, 210000 Nanjing, Jiangsu, China.
Background: Pre-eclampsia (PE) is a gestational disorder that significantly endangers maternal and fetal health. Transfer ribonucleic acid (tRNA)-derived small RNAs (tsRNAs) are important in the progression and diagnosis of various diseases. However, their role in the development of PE is unclear.
View Article and Find Full Text PDFDecreased PD-L1 contributes to preeclampsia by suppressing GM-CSF via the JAK2/STAT5 signal pathway.
Sci Rep
January 2025
Department of Obstetrics, The First Hospital of China Medical University, Shenyang, 110000, Liaoning, China.
Programmed cell death protein 1 (PD-1) and its ligand PD-L1 have been detected at the materno-embryonic interface in both human and murine pregnancy models. However, research regarding the PD-1/PD-L1 signal in preeclampsia (PE) is limited. In the present investigation, 30 normal pregnant females and 30 PE patients were enrolled.
View Article and Find Full Text PDFEffects of Exosome miR-494 on Proliferation, Migration, and Invasion of Trophoblastic Cells by Regulating the PTEN/PI3K/Akt Pathway.
Ann Clin Lab Sci
November 2024
Department of Pathology, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong, China.
Objective: To investigate the effects of the exosomal miR-494 targeting phospholipinositol 3-kinase (PI3K)/protein kinase B (AKT)/rapamycin target protein (mTOR) pathway on proliferation, migration, and invasion of trophoblast cells.
Methods: Decidual macrophages were randomly divided into control group, mimic NC group, miR-494 mimic group, inhibitor NC group, and miR-494 inhibitor group. Each group was transfected with corresponding miR-494 mimic NC, miR-494 mimic, and inhibitor NC and miR-494 inhibitor, while the cells of control group were only replaced with fresh medium.
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