Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Role of Plant Bioactive as Diuretics: General Considerations and Mechanism of Diuresis.
Curr Hypertens Rev
September 2023
Faculty of Pharmacy, Integral University, Lucknow, India.
Background: Medicinal plants have been found beneficial in the control and therapy of many ailments as they contain bioactive compounds, and many of them are used as precursors in the biosynthesis of natural medicines. Diuretics are used as a primary treatment in patients with edema associated with liver cirrhosis and kidney diseases, hyperkalemia, hypertension, heart failure, or renal failure. Furthermore, they are also used to increase the excretion of sodium and reduce blood volume.
View Article and Find Full Text PDFDraining the edema: a new role for aquaretics?
Pediatr Nephrol
May 2014
Great Ormond Street Hospital for Children NHS Foundation Trust and Institute of Child Health, University College London, 30 Guildford Street, London, WC1N 1EH, UK,
Investigations into edema formation in nephrotic syndrome have mostly focused on the primary role of sodium. While there is controversy about whether sodium retention is an inherent aspect of nephrotic syndrome (overfill hypothesis) or a secondary consequence (underfill hypothesis), the critical role of sodium in driving fluid retention is generally accepted. Consequently, treatment of edema is based on enhancing renal sodium excretion, using saluretics to block tubular reabsorption of sodium.
View Article and Find Full Text PDFNonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene.
Exp Clin Endocrinol Diabetes
August 1999
Department of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
After the story of success of hormone blockers for catecholamines, aldosterone and angiotensin II and their successful implementation into clinical practice another endocrine cardiovascular system has come into focus. It has long been known, that the hormone vasopressin plays an important role in peripheral vasoconstriction, hypertension and in several disease conditions with dilutional hyponatremia in edematous disorders, like congestive heart failure, liver cirrhosis, SIADH and nephrotic syndrome. A series of orally active nonpeptide antagonists against the vasopressin receptor subtypes has recently been synthesized and is now under intensive examination.
View Article and Find Full Text PDF[The loop diuretic bumetanide as a tool in physiology and pharmacology].
Dtsch Tierarztl Wochenschr
October 1992
Institut für Pharmakologie und Toxikologie, Fachbereich Veterinärmedizin, Universität Giessen.
Loop diuretics are derivatives of 4-sulfamoylbenzoic acid, which derived originally from sulfonamides. Their diuretic effect is due to the inhibition of the Na-K-Cl-cotransport system in the distal part of Henle's loop. The compounds react with different affinity with the chloride binding site of the transporter.
View Article and Find Full Text PDFTen male cirrhotic patients with ascites and reduced renal function were randomly given equivalent doses of furosemide and muzolimine by the oral route, through a single blind cross-over protocol. Renal function, electrolyte plasma concentrations and urinary excretions and renin-angiotensin-aldosterone system components were evaluated under basal conditions and after drug administration. The diuretic and saluretic effects being equal, the response to muzolimine was initially weaker but more prolonged than to furosemide, without rebound phenomena.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!