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Aerolysin Nanopore Electrochemistry.
Acc Chem Res
January 2025
Molecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
ConspectusIons are the crucial signaling components for living organisms. In cells, their transportation across pore-forming membrane proteins is vital for regulating physiological functions, such as generating ionic current signals in response to target molecule recognition. This ion transport is affected by confined interactions and local environments within the protein pore.
View Article and Find Full Text PDFLong-term nitrogen fertilization alters the partitioning of amino acids between citrus leaves and fruits.
Front Plant Sci
January 2025
Center of Molecular Ecophysiology (CMEP), College of Resources and Environment, Southwest University, Chongqing, China.
Introduction: The growth of evergreen fruit trees is influenced by the interaction of soil nitrogen (N) and leaf amino acid contents. However, information on free amino acid contents in leaves of fruiting and non-fruiting branches during long-term N fertilizer application remains scarce.
Methods: Here, a four-year field experiment (2018-2021) in a citrus orchard revealed consistently lower total N and amino acid contents in leaves of fruiting compared to non-fruiting branches.
Thermodynamics Properties of Leucine and Isoleucine Peptides in Water.
ChemistryOpen
January 2025
Central Department of Physics, Tribhuvan University, Kathmandu, Nepal.
Thermodynamic properties of amino acids explore the ideas about the energetic contribution in biomolecular interfaces. In our work, we have estimated the solvation free energy of leucine and isoleucine peptides with the variation of chain length or residues of different monomer units (n=1, 2, 4, 8 & 16) using molecular dynamic simulation. We modeled our system using OPLS-AA force field and TIP3P water model at 310 K temperature.
View Article and Find Full Text PDFImpact of Phosphorylation and O-GlcNAcylation on the Binding Affinity of R4 Tau Peptide to Microtubule and Its Conformational Preference upon Dissociation.
J Chem Inf Model
January 2025
Department of Chemistry, Faculty of Science, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Tau is a microtubule (MT)-associated protein that binds to and stabilizes the MTs of neurons. Due to its intrinsically disordered nature, it undergoes several post-translational modifications (PTMs) that are intricately linked to both the physiological and pathophysiological roles of Tau. Prior research has shown phosphorylation and O-GlcNAcylation to have contrasting effects on Tau aggregation; however, the precise molecular mechanisms and potential synergistic effects of these modifications remain elusive.
View Article and Find Full Text PDFThe characteristics of aminotransferases gene family in Ruditapes philippinarum and its response to salinity stresses.
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
College of Fisheries and Life Science, Dalian Ocean University, 116023 Dalian, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian Ocean University, 116023 Dalian, China.
Aminotransferase is involved in the regulation of amino acid metabolism, which can affect the balance and distribution of amino acids in the organism, help maintain the homeostasis of amino acids in the organism, and play an important role in the environmental adaptation of aquatic animals. In this study, a total of 28 aminotransferase genes were identified in the genome of R. philippinarum.
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