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Dialysis and lyophilization of the mesenchymal stromal cell secretome for wound healing.
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Regenerative Medicine Laboratory, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune 411018, India.
Background Aims: The clinical translation of mesenchymal stromal cell secretome (MSC-S) has been challenging owing to a lack of appropriate methods in downstream processing. Dialysis is an age-old method of protein purification by the exchange of small molecules through a semi-permeable membrane. In this study, we investigated the potential of three forms of umbilical cord-derived MSC secretome (UC-MSC-S)-native (S), dialyzed (DS), and lyophilized (LDS)-for wound healing applications.
View Article and Find Full Text PDFA polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against HO-induced oxidative damage.
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State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, PR China; State Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, PR China; College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, PR China. Electronic address:
Morchella esculenta (L.) Pers. is considered a precious edible and medicinal fungus due to its strict growth environment requirements, difficult to cultivate, resulted in expensive in the market.
View Article and Find Full Text PDFEnvironmentally relevant concentrations of DBDPE (decabromodiphenyl ethane) induce intestinal toxicity in silkworms (Bombyx mori L.).
Environ Pollut
January 2025
Nanjing Institute of Environmental Science, Ministry of Ecology and Environment of China, Nanjing 210042, China; Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Ecology and Environmental of China, Nanjing 210042, China. Electronic address:
Decabromodiphenyl ethane (DBDPE) is one of the most extensively used novel brominated flame retardants, and it has been frequently detected in the global environment. Although organisms encounter various pollutants through the intestine, the toxicity effects of DBDPE exposure on the intestine and the potential mechanisms remain unclear. Here, by morphological observation, histopathology, high-throughput sequencing, and transcriptomics methods, we evaluated the effects of environmental (0.
View Article and Find Full Text PDFThymol inhibits ergosterol biosynthesis in Nakaseomyces glabratus, but differently from azole antifungals.
J Mycol Med
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Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
Introduction: Nakaseomyces glabratus is considered a high priority of attention according to WHO, and also is an important yeast species due to its high rate of intrinsic/acquired resistance against fluconazole. This study aimed at the possible mechanisms of action of thymol, as the promising new antifungal agent, in N. glabratus.
View Article and Find Full Text PDFLong-term suppression of Microcystis aeruginosa by tannic acid: Risks of microcystin pollution and proteomic mechanisms.
J Hazard Mater
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School of Environment, Jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology, Nanjing Normal University, Nanjing 210023, China; Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application, Nanjing 210023, China. Electronic address:
Harmful algal blooms are a critical eco-environmental issue with severe impacts on aquatic ecosystems and human health. Tannic acid (TA) has been suggested as an effective algal bloom control, but the molecular mechanisms of its interaction with algae cells and its effects on algal toxin release remain unclear. This study tracked toxin production and release in the toxigenic species Microcystis aeruginosa (M.
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