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Tau pathology in the locus coeruleus (LC) is associated with several neurodegenerative conditions including Alzheimer's disease and frontotemporal dementia. Phosphorylated tau accumulates in the LC and results in inflammation, synaptic loss, and eventually cell death as the disease progresses. Loss of LC neurons and noradrenergic innervation is thought to contribute to the symptoms of cognitive decline later in disease.
View Article and Find Full Text PDFImproving auditory attention decoding by classifying intracranial responses to glimpsed and masked acoustic events.
Imaging Neurosci (Camb)
April 2024
Department of Electrical Engineering, Columbia University, New York, NY, United States.
Listeners with hearing loss have trouble following a conversation in multitalker environments. While modern hearing aids can generally amplify speech, these devices are unable to tune into a target speaker without first knowing to which speaker a user aims to attend. Brain-controlled hearing aids have been proposed using auditory attention decoding (AAD) methods, but current methods use the same model to compare the speech stimulus and neural response, regardless of the dynamic overlap between talkers which is known to influence neural encoding.
View Article and Find Full Text PDFTemporal Dynamics of Moderate-Intensity Transcranial Static Magnetic Stimulation in Young Adults.
J Clin Med Res
January 2025
Department of Rehabilitation Medicine, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China.
Background: Transcranial static magnetic stimulation (tSMS) as a new noninvasive brain stimulation (NIBS) technique is gradually gaining widespread attention. This study aims to investigate the effects of tSMS on the excitability of the somatosensory cortex in healthy adults.
Methods: Forty healthy volunteers were recruited and randomly assigned to either the intervention group (tSMS) or the control group (sham), with 20 participants in each.
Nuclear calcium signaling in D1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine.
Biol Psychiatry
January 2025
Institute of Biology Paris-Seine, laboratory Neuroscience Paris-Seine, CNRS, INSERM, Sorbonne Université, UPMC Université Paris 06 F-75005, Paris, France. Electronic address:
Background: The persistence of cocaine-evoked adaptations relies on gene regulations within the reward circuit, especially in the ventral striatum (i.e., nucleus accumbens (NAc)).
View Article and Find Full Text PDFExploring the Pathophysiology, Diagnosis, and Treatment Options of Multiple Sclerosis.
J Integr Neurosci
January 2025
Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
The complicated neurological syndrome known as multiple sclerosis (MS) is typified by demyelination, inflammation, and neurodegeneration in the central nervous system (CNS). Managing this crippling illness requires an understanding of the complex interactions between neurophysiological systems, diagnostic techniques, and therapeutic methods. A complex series of processes, including immunological dysregulation, inflammation, and neurodegeneration, are involved in the pathogenesis of MS.
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