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Psychosocial and physical wellbeing in women and male partners undergoing immediate versus postponed modified natural cycle frozen embryo transfer after ovarian stimulation and oocyte pick-up: a sub-study of a randomized controlled trial.
Hum Reprod
January 2025
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Study Question: Are there differences in psychosocial and physical wellbeing among women and male partners undergoing modified natural cycle (mNC) frozen embryo transfer (FET) in immediate compared to postponed cycles after ovarian stimulation (OS) and oocyte pick-up (OPU)?
Summary Answer: Significantly more women in the immediate group reported physical symptoms than women in the postponed group whilst fewer were emotionally affected by waiting time, although the latter difference lost statistical significance after adjustment for multiple testing.
What Is Known Already: Infertility and fertility treatment are known to cause psychosocial distress in women and couples longing for a child. The treatment may be long-term and delayed for various reasons, such as the elective postponement of FET after a fresh transfer without pregnancy or an elective freeze-all cycle, possibly further increasing the level of distress.
The impact of adherence counseling incorporating a point of care urine tenofovir assay on virologic suppression among individuals failing tenofovir-lamivudine-dolutegravir: A pre-post intervention study.
Int J Infect Dis
February 2025
Centers for Disease Control and Prevention, Division of Global HIV and Tuberculosis, Atlanta, Georgia, USA.
Objectives: To examine if point-of-care (POC) urine tenofovir testing-informed counseling could be used to improve virologic suppression (VS) among participants with virologic failure (VF) after ≥1 prior round of enhanced adherence counseling (EAC).
Methods: Participants were enrolled from 42 clinics across Namibia. At each monthly medication pick-up, participants completed the POC urine test and received EAC informed by this testing (EAC+).
Assessment of cancer predisposition syndromes in children with leukemia and solid tumors: germline-genomic profiling and clinical features in a series of cases.
Pediatr Hematol Oncol
November 2024
Pediatric Hematology Oncology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- - Cancer predisposition syndromes (CPS) are genetic disorders that raise cancer risk, yet many children in low- and middle-income countries go undiagnosed, impacting treatment and family counseling.
- - In a study of 60 pediatric oncology patients, six were identified with CPS, confirmed through whole exome sequencing that detected germline mutations in five cases, including two novel mutations.
- - The study found a 10% prevalence of CPS among the patients and suggests that using specific selection criteria for screening could improve diagnosis and treatment modifications in pediatric cancer patients in LMIC settings.
Multidisciplinary Treatment for Breast Cancer-related Multiple Bone Metastases during Pregnancy Using Bone Metastasis Cancer Boards: A Case Report.
Prog Rehabil Med
October 2024
Department of Physical Medicine and Rehabilitation, Kobe University Hospital, Kobe, Japan.
Article Synopsis
- - A multidisciplinary approach using Bone Metastasis Cancer Boards (BMCBs) has been utilized since 2013 to manage patients at risk of skeletal-related events (SREs), focusing on teamwork for the best treatment outcomes.
- - A pregnant 41-year-old woman with breast cancer and multiple bone metastases received coordinated care through a BMCB, which led to a successful cesarean section and subsequent rehabilitation therapy.
- - The BMCB not only addressed the patient’s immediate treatment needs but also helped improve her daily activities and overall well-being, highlighting the potential of BMCBs in preventing SREs and enhancing rehabilitation for similar patients.
Prospective cohort for early detection of liver cancer (Pearl): a study protocol.
BMJ Open
October 2024
Members of the DeLIVER consortium and their associated institutions are listed in the collaborators section, UK.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a type of liver cancer that is becoming more common and is the fourth leading cause of cancer deaths worldwide, especially in people with liver cirrhosis.
- The study aims to find early signs of HCC in patients with cirrhosis by using better tests and involves tracking around 3,000 patients over several years.
- The research is approved by ethics boards, and the findings will be shared publicly to help improve cancer detection and treatment.
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