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Tyrosinyl-amantadine: A New Amantadine Derivative With an Ameliorative Effect in a 6-OHDA Experimental Model of Parkinson's Disease in Rats.
J Mol Neurosci
April 2022
Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St, Block 23, Sofia,, 1113, Bulgaria.
The neuroprotective capacity of newly synthesized amantadine derivative tyrosinyl-amantadine (Tyr-Am) with expected antiparkinsonian properties was evaluated in a 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. Male Wistar rats were divided into the following groups: sham-operated (SO), striatal 6-OHDA-lesioned control group, 6-OHDA-lesioned rats pretreated for 6 days with Tyr-Am (16 mg/kg administered intraperitoneally, i.p.
View Article and Find Full Text PDFBeneficial Effect of Melatonin on Motor and Memory Disturbances in 6-OHDA-Lesioned Rats.
J Mol Neurosci
April 2021
Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G, Bonchev Str., bl. 23, Sofia, 1113, Bulgaria.
Previous evidence has shown a link between neurodegenerative diseases, including Parkinson's disease (PD), and melatonin. The data in the literature about the impact of the hormone under different experimental PD conditions are quite controversial, and its effect on memory impairment in the disease is very poorly explored. The current research was aimed at investigating the role of melatonin pretreatment on memory and motor behavior in healthy rats and those with the partial 6-hydroxydopamine (6-OHDA) model of PD.
View Article and Find Full Text PDF[Bulgarian antiparkinson preparations with a new mechanism of action].
Zh Nevropatol Psikhiatr Im S S Korsakova
October 1968
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