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Juvenile chronic social defeat stress reduces prosocial behavior in adult male mice.
Pharmacol Biochem Behav
February 2025
Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology (SZX2020013), Hebei Medical University, 050017, China. Electronic address:
Exposure to stress in early life can have a significant impact on individuals. However, the effects of early-life stress (ELS) on prosocial behavior remain unclear, as do the underlying mechanisms. In this study, ICR juvenile mice were subjected to juvenile chronic social defeat stress (jCSDS) between postnatal days 32 and 41, during which body weight changes were continuously monitored.
View Article and Find Full Text PDFEfficacy and Safety of a Low-FODMAP Diet in Combination with a Gluten-Free Diet for Adult Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.
Dig Dis Sci
November 2024
School of Nursing, Yangzhou University, 136 Jiangyang Road, Yangzhou, Jiangsu, China.
Background: Common gastrointestinal disease irritable bowel syndrome (IBS) is marked by symptoms like changed bowel habits, bloating, and stomach ache. A low-FODMAP combined gluten-free diet (LF-GFD) has been suggested as a possible therapy for IBS symptoms management.
Objective: This study sought to investigate whether a LF-GFD would help patients with IBS.
Chronic stress induces insulin resistance and enhances cognitive impairment in AD.
Brain Res Bull
October 2024
Department of Neurology, Hebei Hospital, Xuanwu Hospital of Capital Medical University, Shijiazhuang, Hebei, China; Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, China. Electronic address:
Article Synopsis
- Chronic stress negatively affects insulin resistance and glucose metabolism, both of which are linked to cognitive decline and the development of Alzheimer's disease (AD).
- An experiment involving 9-month-old mice demonstrated that exposure to chronic unpredictable mild stress (CUMS) for 4 weeks decreased insulin sensitivity and altered key protein expressions related to glucose metabolism in the hippocampus.
- Cognitive assessments revealed that CUMS exposure led to significant impairments in cognitive function in both wild-type and APP/PS1 mice, indicating a possible connection between chronic stress, insulin resistance, and cognitive decline.
The effect of predictive nursing on the mental state, compliance and sleep quality of senile cervicitis: An observational study.
Medicine (Baltimore)
May 2024
Department of Intensive Care Medicine, Cardiovascular Hospital, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
To explore the effect of predictive nursing on the mental state, compliance and sleep quality of elderly patients with cervicitis. The clinical data of 96 elderly patients with cervicitis who were admitted to our hospital from June 2019 to June 2021 were selected as the research objects. According to the different treatments, they were divided into a control group and an observation group with 48 cases each.
View Article and Find Full Text PDFStudy on the impact of comprehensive geriatric assessment on anxiety and depression in chronic obstructive pulmonary disease patients.
World J Clin Cases
July 2024
Respiratory and Critical Care Medicine, The First People's Hospital of Jiangxia District, Wuhan 430000, Hubei Province, China.
Article Synopsis
- Psychological issues like anxiety and depression worsen symptoms and quality of life in COPD patients, making it essential to study comprehensive assessments in treating these conditions in the elderly.
- The study compares two groups of COPD patients—one receiving routine care and the other receiving comprehensive assessments—looking at their symptoms, quality of life, and psychological factors.
- Results show that the group receiving comprehensive assessments had improved quality of life and lower anxiety and depression scores compared to the control group, demonstrating the effectiveness of this approach in COPD care.
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