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Introduction: Ethnomedicinal plants in Asia offer a promising, low-side-effect alternative to synthetic drugs for treating fungal infections, one of the most widespread communicable diseases caused by pathogenic fungi. Despite being underexplored, the region's rich plant diversity holds the potential for developing effective antifungal drugs. Research is increasingly focused on bioactive compounds from these plants, which show strong antifungal properties and may serve as leads for new drug development.

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Use of dielectric-barrier discharge (DBD) cold plasma for control of bread spoilage fungi.

Int J Food Microbiol

December 2024

Department of Food Engineering and Technology, School of Food Engineering, Universidade Estadual de Campinas, São Paulo, Brazil. Electronic address:

Bread is a greatly consumed bakery product worldwide. Unfortunately, it is an optimal substrate for fungal contamination and deterioration (aw > 0.95), commonly caused by the genera Penicillium, Paecilomyces, and Aspergillus, resulting in significant economic losses.

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Candidiasis is an infectious disease caused by some fungi of the genus Candida. In Brazil, the incidence rate is higher than in European countries and the United States, and health problems occur mainly due to the virulence factors of the fungi, which have made treatment with commercial drugs difficult. Considering the context, plants rich in phenolic compounds, such as those of the genus Piper, have been studied due to their antimicrobial properties.

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Article Synopsis
  • The study investigates the antifungal properties of hypericin when nanoencapsulated in P123 copolymer micelles, focusing on its photodynamic therapy (PDT) mechanisms.
  • Key methods include antifungal susceptibility tests to determine minimum fungicidal concentration, time-kill curves, and flow cytometry to analyze the internalization of the nanoencapsulation and the production of reactive oxygen species (ROS).
  • Results indicate that P123-Hyp maintains fungistatic activity for up to 24 hours, with evidence of necrotic cell death and disruption of the fungal plasma membrane through the activation of type II PDT pathways.
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Cm-p5, a molluscan-derived antifungal peptide exerts its activity by a membrane surface covering in a non-penetrating mode.

Peptides

December 2024

Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México (ICF-UNAM), Av. Universidad S/N, Chamilpa, Cuernavaca, Morelos 62210, México. Electronic address:

Amidst the health crisis caused by the rise of multi-resistant pathogenic microorganisms, Antimicrobial Peptides (AMPs) have emerged as a potential alternative to traditional antibiotics. In this sense, Cm-p5 is an AMP with fungistatic activity against the yeast Candida albicans. Its antimicrobial activity and selectivity have been well characterized; however, the mechanism of action is still unknown.

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