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Disaccharidase Enzyme Deficiency in Adult Patients with Gas and Bloating.
Clin Transl Gastroenterol
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Wellstar Medical College of Georgia, Augusta University, Augusta, Georgia.
Introduction: Disaccharidases produced by the small intestinal brush border facilitate digestion of dietary carbohydrates. If deficient, they can cause carbohydrate malabsorption resulting in several abdominal symptoms. Our aim was to examine the prevalence of disaccharidase deficiency and correlate this with abdominal symptoms in adult patients with chronic abdominal symptoms.
View Article and Find Full Text PDFEnterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.
Nat Commun
January 2025
Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Colorectal cancer (CRC) is stratified into four consensus molecular subtypes (CMS1-4). CMS3 represents the metabolic subtype, but its wiring remains largely undefined. To identify the underlying tumorigenesis of CMS3, organoids derived from 16 genetically engineered mouse models are analyzed.
View Article and Find Full Text PDFExpression of Recombinant Human α-Glucosidase in HEK293 Cells.
J Agric Food Chem
January 2025
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
In mammals, intestinal α-glucosidase exists as a maltase-glucoamylase complex (MGAM) and a sucrase-isomaltase complex (SI). In this study, we transiently expressed human MGAM and SI in human embryonic kidney 293 (HEK293) cells. At pH 6.
View Article and Find Full Text PDFInfluence of Alkaline Reduced Water Supplementation on Glucose and Lipid Metabolism in Non-Diabetic and Diabetic Rats.
Nutrients
November 2024
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan.
Background: With the global increase in metabolic disorders, identifying effective dietary strategies is crucial for enhancing health outcomes. While various health advantages of alkaline reduced water (ARW) have been documented, its specific impacts on glucose and lipid metabolism in both healthy and diabetic conditions are still not well understood.
Methods: This study investigates how ARW affects carbohydrate and lipid metabolism in male Wistar rats, which were induced to develop glucose metabolism disorders through subcutaneous injections of nicotinamide and streptozotocin (STZ).
A cross-sectional study of associations between the C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy.
Am J Clin Nutr
December 2024
Rutgers Global Health Institute, Department of Biostatistics and Epidemiology, School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States. Electronic address:
Article Synopsis
- Environmental enteropathy (EE) is a condition affecting children in low-resource settings due to exposure to enteric pathogens, and a new noninvasive breath test (C-SBT) to assess carbohydrate digestion was developed and validated.
- The study aimed to link the C-SBT results to the lactulose/rhamnose ratio (LR) and identify their relationship with child growth, as well as investigate connections with socio-economic factors, dietary diversity, and other EE biomarkers.
- Results indicated variability in C-SBT and LR measurements across different sites, with some associations found between child growth and test timing, but no significant links between C-SBT and LR or overall growth metrics were established.
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