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Extraintestinal Manifestations and Family History of Inflammatory Bowel Disease Increase the Risk of Pouchitis in a State-Level Epidemiology Study.
Clin Transl Gastroenterol
February 2024
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA.
Introduction: Our understanding of the epidemiology of inflammatory conditions of the pouch and effectiveness of treatment is largely based on selected populations. We created a state-level registry to evaluate the incidence of pouchitis and the effectiveness of treatments used in an initial episode of pouchitis.
Methods: In a state-level retrospective cohort of all patients undergoing proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis between January 1, 2018, and December 31, 2020, we evaluated the incidence of pouchitis and compared the proportion of patients developing recurrent pouchitis and chronic antibiotic-dependent pouchitis according to initial antibiotic therapy.
AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders.
Gastroenterology
January 2024
Division of Gastroenterology, University of California San Diego, La Jolla, California.
Article Synopsis
- Pouchitis is a common issue after surgery for ulcerative colitis, and the AGA has developed guidelines to help doctors manage this condition effectively.
- A panel assessed clinical questions and outcomes to create 9 recommendations for treating pouchitis, Crohn's-like disease, and cuffitis.
- Key recommendations include using antibiotics for intermittent pouchitis, considering probiotics for prevention, and exploring advanced immunosuppressive therapies for chronic cases or those resistant to antibiotics.
Dietary Patterns Are Not Associated With Disease Activity Among Patients With Inflammatory Conditions of the Pouch in a Prospective Cohort.
Crohns Colitis 360
July 2023
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.
Background: Evidence-based recommendations regarding the influence of diet on inflammatory conditions of the pouch after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) are limited.
Methods: We analyzed dietary patterns at enrollment in a prospective registry of patients with 1 of 4 inflammatory conditions of the pouch (acute pouchitis, chronic antibiotic-dependent pouchitis, chronic antibiotic refractory pouchitis, and Crohn's disease of the pouch). We analyzed dietary intake by disease activity at enrollment and then compared dietary patterns among patients who remained in remission throughout the 12-month follow-up to those patients who experienced a disease relapse.
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