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In 25-40 years after pneumonectomy conduction the mediastinal hernia (MH) occurred in 62.4% of 210 patients. Principal clinico-radiological signs of MH were vicarious hypertrophy and true pulmonary emphysema.

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A one-month repeated oral dose toxicity study of methotrexate in unilaterally nephrectomized rats.

J Toxicol Sci

November 1998

Medical Research Laboratories, Lederle (Japan), Ltd., Saitama, Japan.

A repeated oral dose toxicity study of methotrexate (MTX) was conducted in order to examine whether the enhancement of MTX toxicity would occur in unilaterally nephrectomized (UNX) rats. UNX rats or sham-treated (SHAM) rats received dosages of 0, 0.06, 0.

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The variations occurring in neurons from dorsal root ganglia that provide innervation to the regenerated tail of the lizard (vicarious ganglia) are analysed. Vicarious ganglion neurons, when compared to control ganglion neurons (i.e.

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The hyperplasia of the palatine tonsils, which can be often found in children suffering from the so-called "lymphatism", cannot be considered a pathological state; it simply indicates the attempt of the organism to restore a functional balance between the antigenic shock on one hand and the unitary inadequacy of the lymphatic cells to performs their tasks on the other hand. However, this hyperplasia is sometimes so serious to cause respiratory ailments and predispose several pathologies: in these cases, a surgical operation becomes necessary. Since the tonsillectomy deprives these children of the important defensive barrier represented by the palatine tonsils and the results given by the monotonsillectomy have proved to be not completely satisfactory, both for the phlogosis and for the vicarious hypertrophy of the remaining tonsil, the Authors propose a new surgical technique (never suggested before) in cases of mechanical oropharyngeal obstruction due to hyperplasia of the palatine tonsils.

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Dysphonia plica ventricularis involves the faulty participation of the ventricular folds in the act of phonation. The speech disorder was one of the first to be described with the use of indirect laryngoscopy. This dysphonia can occur as a compensation for anatomic or physiologic alterations within the larynx (vicarious type) or as isolated ventricular fold hypertrophy unaccompanied by other obvious laryngeal disorders (usurpative type).

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