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Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis.
Mol Med
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Background: Lysinuric protein intolerance is a rare autosomal disorder caused by mutations in the Slc7a7 gene that lead to impaired transport of neutral and basic amino acids. The gold standard treatment for lysinuric protein intolerance involves a low-protein diet and citrulline supplementation. While this approach partially improves cationic amino acid plasma levels and alleviates some symptoms, long-term treatment is suggested to be detrimental and may lead to life-threatening complications characterized by a wide range of hematological and immunological abnormalities.
View Article and Find Full Text PDF[An Endemic Disease in the Black Sea Region: Leptospirosis].
Mikrobiyol Bul
January 2025
Sağlık Bilimleri Üniversitesi, Samsun Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Samsun.
Leptospiroz, insan ve hayvanları etkileyen, Antarktika hariç tüm kıtalarda bulunan ve Leptospira cinsi spiroketlerin neden olduğu zoonotik bir enfeksiyon hastalığıdır. Salgınlara yol açabilmesi nedeniyle halk sağlığı açısından önemli bir hastalıktır. Bu çalışmada; kliniğimizde leptospiroz tanısıyla izlenen 11 olgunun, epidemiyolojik özellikleri, saptanan etkenler, klinik ve laboratuvar bulguları açısından retrospektif olarak değerlendirilmesi amaçlanmıştır.
View Article and Find Full Text PDFPerformance of Extracellular Vesicles From () for Serological Diagnosis of Human and Canine Visceral Leishmaniasis.
J Parasitol Res
January 2025
Parasitology and Mycology Center, Adolfo Lutz Institute, Sao Paulo, Brazil.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
View Article and Find Full Text PDFBryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11.
Front Immunol
January 2025
Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
Introduction: Bryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and cancer therapies. In HIV research, it has shown anti-HIV effects during acute infection and reactivation of latent HIV in chronic infection. As effective CD8+ T cell responses are essential for eliminating reactivated virus and achieving a cure, it is important to investigate how bryostatin-1 affects HIV-specific CD8+ T cells.
View Article and Find Full Text PDFDynamic trends of dengue fever serotypes in northern India: Exploring clinical manifestations, serotype dissemination, and the influence of mixed infections.
Trop Biomed
December 2024
Department of Microbiology, ESIC Medical College & Hospital, Faridabad, 121001, Haryana, India.
Examining the co-circulation of various serotypes and finding serotypes linked to illness severity were the main objectives of this study, which sought to investigate the epidemiology and serotype distribution of dengue in Haryana, North India. The cross-sectional study, which was carried out in a tertiary care hospital between September 2021 and April 2023, enrolled participants who met WHO criteria for probable dengue fever. Blood samples underwent molecular and serological diagnostics, such as immunochromatographic testing, VIDAS® Dengue NS1 assays, and TRUPCR® Dengue Detection and serotyping kits, in addition to the collection of clinical and demographic data.
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