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Article Synopsis
  • Bullous emphysema is a chronic lung disease marked by the presence of large air spaces called bullae, with giant bullae being particularly significant and often requiring surgical removal known as bullectomy.
  • A 35-year-old man with a history of COVID-19 experienced chest pain and difficulty breathing, leading to the discovery of a giant bulla in his left lung on imaging scans.
  • Remarkably, after monitoring over several months, the giant bulla spontaneously resolved without surgery, suggesting that infectious processes may play a role in this phenomenon, highlighting the importance of careful imaging and follow-up in similar cases.
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Aim: Increasing observational studies are revealing a positive correlation between body mass index (BMI) and the risk of Immune-mediated and Inflammatory Skin Diseases (IMID), however the causal relationship is not yet definite.

Objective: The aim of the study was to conduct a two-sample Mendelian randomization (TSMR) to explore the potential causality between BMI, and IMID and biomarkers.

Methods: The summary statistics for BMI (n = 322,154), at genome-wide significant level, were derived from the Genetic Investigation of Anthropometric Traits consortium (GIANT).

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Herpes zoster is a clinical syndrome associated with reactivation of varicella zoster virus (VZV), often occurring years after VZV infection, and characterized typically by painful grouped vesicles in a dermatomal distribution. Bullous herpes zoster, an atypical presentation of herpes zoster, is a relatively rare phenomenon; to the authors' knowledge, there have only been eight reports in worldwide literature. We present a case of a 59-year-old female with lupus nephritis who presented with multiple grouped vesicles evolving into large tender bullae filled with serosanguinous fluid on the lateral aspect of the right leg, and dorsal and medial aspects of the right foot, four days after the first dose of 1g of rituximab therapy.

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