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Methyl Syringate Monoglucoside Is a Crucial Intermediate in Leptosperin Biosynthesis in (ma̅nuka).
J Agric Food Chem
January 2025
Faculty of Health and Nutrition, Shubun University, Ichinomiya, Aichi 491-0938, Japan.
Leptosperin (methyl syringate-4--β-d-gentiobioside) serves as a unique marker for ma̅nuka honey, derived from the ma̅nuka plant (). Despite its importance, the biosynthesis pathway of leptosperin remains unreported. This study investigates the molecular mechanism of leptosperin formation from its aglycone, methyl syringate (MSYR), in ma̅nuka plants.
View Article and Find Full Text PDFBirth and pregnancy numbers decreased during the COVID-19 pandemic in Japan: A time series analysis with the ARIMA model.
J Obstet Gynaecol Res
January 2025
Department of Public Health, Dokkyo Medical University, School of Medicine, Tochigi, Japan.
Aim: The long-term effects of the COVID-19 pandemic on birth and pregnancy trends in Japan remain unclear. Although major sporting events are usually followed by an increase in births 9 months later, Japan's fifth wave of COVID-19 occurred during the Olympics held in Japan during the summer of 2021. In this study, we analyzed how the number of births and pregnancies changed during the COVID-19 pandemic and large-scale events in Japan.
View Article and Find Full Text PDFComputed tomography for diagnosis of tiny acute myocardial infarction with microvascular obstruction.
Int J Cardiovasc Imaging
January 2025
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Advanced Varus Deformity Associated with Medial Knee Osteoarthritis is a Potential Predictor of Anterior Cruciate Ligament Tear and Risk for Suitable Unicompartmental Knee Arthroplasty.
J Arthroplasty
January 2025
Department of Orthopedic Surgery, Nishinomiya Watanabe Hospital, Hyogo, Japan.
Background: Previous clinical studies suggest that preserving the anterior cruciate ligament (ACL) is crucial for stable knee motion and long-term longevity of the reconstructed knee. The ACL damage or loss often occurs in advanced medial osteoarthritis (OA). This study aimed to investigate the correlation between ACL damage and varus deformity progression as a risk factor for ACL tears in knee OA.
View Article and Find Full Text PDFSingle-Cell RNA-Sequencing of Zebrafish Olfactory Epithelium Identifies Odor-Responsive Candidate Olfactory Receptors.
Genes Cells
January 2025
Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Saitama, Japan.
Single-cell RNA-sequencing (scRNA-seq) is a powerful method to comprehensively overlook gene expression profiles of individual cells in various tissues, providing fundamental datasets for classification of cell types and further functional analyses. Here we adopted scRNA-seq analysis for the zebrafish olfactory sensory neurons which respond to water-borne odorants and pheromones to elicit various behaviors crucial for survival and species preservation. Firstly, a single-cell dissociation procedure of the zebrafish olfactory rosettes was optimized by using cold-active protease, minimizing artifactual neuronal activation.
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