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Connecting the dots: Low-grade appendiceal mucinous neoplasms and serrated polyps in the appendix.
Am J Clin Pathol
January 2025
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States.
Objective: This study aimed to examine the relationship between low-grade appendiceal mucinous neoplasms (LAMNs) and serrated polyps (SPs) of the appendix, both characterized by KRAS mutations and overlapping morphologic features.
Methods: We analyzed 27 cases of LAMN and 24 cases of SP from archival records, reviewed pathology, and performed molecular analysis on select cases. Four cases initially diagnosed as LAMN were excluded for not meeting diagnostic criteria, and 1 SP case was reclassified as LAMN.
Genomics-assisted stacking of waxy1, opaque2, and crtRB1 genes for enhancing amylopectin in biofortified maize for industrial utilization and nutritional security.
Funct Integr Genomics
January 2025
ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India.
Waxy maize is highly preferred diet in developing countries due to its high amylopectin content. Enriching amylopectin in biofortified maize meets food security and fulfils the demand of rising industrial applications, especially bioethanol. The mutant waxy1 (wx1) gene is responsible for increased amylopectin in maize starch, with a wide range of food and industrial applications.
View Article and Find Full Text PDFAssessment of viable tumours by [Ga]Ga-FAPI-04 PET/CT after local regional treatment in patients with hepatocellular carcinoma.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine and PET, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Purpose: To investigate the efficacy of [Ga]Ga-FAPI-04 PET/CT for assessing viable tumours (VTs) after local regional treatment (LRT) in hepatocellular carcinoma (HCC) patients. The related imaging features of HCC after LRT are preliminarily discussed.
Methods: A cohort of 37 LRT patients with HCC (encompassing 51 lesions) was retrospectively included from a prospective parent study (ChiCTR2000039099), and sequential PET/CT using [F]FDG and [Ga]Ga-FAPI-04 was performed.
Application of predictive modeling tools for the identification of Ocimum spp. herbal products.
Anal Bioanal Chem
January 2025
Intercollege Graduate Degree Program in Plant Biology, Pennsylvania State University, University Park, PA, USA.
Species identification of botanical products is a crucial aspect of research and regulatory compliance; however, botanical classification can be difficult, especially for morphologically similar species with overlapping genetic and metabolomic markers, like those in the genus Ocimum. Untargeted LC-MS metabolomics coupled with multivariate predictive modeling provides a potential avenue for improving herbal identity investigations, but the current dearth of reference materials for many botanicals limits the applicability of these approaches. This study investigated the potential of using greenhouse-grown authentic Ocimum to build predictive models for classifying commercially available Ocimum products.
View Article and Find Full Text PDFAnalysis of Platelet Morphological Parameters as Clinical Risk Stratification in Acute Coronary Syndrome.
Catheter Cardiovasc Interv
January 2025
Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
Background: Platelet activation plays a central role in the pathogenesis of acute coronary syndrome (ACS). Platelet morphological parameters, including MPV, PDW, and P-LCR, are emerging as biomarkers for predicting the severity of ACS and prognosis.
Aims: This study aims to assess the relationship between these parameters and coronary severity and to evaluate their predicting adverse outcomes.
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