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Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer.
Sci Rep
January 2025
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, 420 Delaware St SE, MMC 609, Minneapolis, MN, 55455, USA.
Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, challenging the fidelity of these models. We employed a quantitative mass spectrometry-based proteomic approach coupled with generation of patient-specific databases using RNA-seq data to investigate the proteogenomic landscape of serially-passaged PDX models established from two patients with distinct subtypes of ovarian cancer.
View Article and Find Full Text PDFTargeting chromosomally unstable tumors with a selective KIF18A inhibitor.
Nat Commun
January 2025
Volastra Therapeutics, New York, NY, USA.
Chromosome instability is a prevalent vulnerability of cancer cells that has yet to be fully exploited therapeutically. To identify genes uniquely essential to chromosomally unstable cells, we mined the Cancer Dependency Map for genes essential in tumor cells with high levels of copy number aberrations. We identify and validate KIF18A, a mitotic kinesin, as a vulnerability of chromosomally unstable cancer cells.
View Article and Find Full Text PDFCase report: Dieulafoy's lesion as a rare cause of massive gastrointestinal hemorrhage.
Int J Surg Case Rep
January 2025
General Surgery Department, Mahmoud El Matri Hospital, V59M+628, Ariana, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, R534+F9H, Rue de la Faculté de Médecine, Tunis, Tunisia.
Introduction And Importance: Dieulafoy's lesion is a rare but serious cause of gastrointestinal bleeding, typically affecting older adults. It involves an aberrant arteriole eroding the gastric mucosa, resulting in severe, recurrent bleeding that poses diagnostic and management challenges. We present a case report of massive gastrointestinal hemorrhage with hemodynamic instability associated with a Dieulafoy's lesion.
View Article and Find Full Text PDFAdvances in studying the pathological mechanisms and treatment strategies of transthyretin amyloidosis.
J Cardiovasc Pharmacol
December 2024
Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Article Synopsis
- Transthyretin amyloidosis (ATTR) is a condition caused by unstable transthyretin protein (TTR) building up in the heart and nerves.
- Therapeutic approaches focus on lowering TTR levels by inhibiting its production in the liver and clearing amyloid deposits from tissues.
- The article also explores TTR's role in disease development, recent treatment advancements, and future research opportunities for better diagnosis and prevention.
A computational and multi-brain signature for aberrant social coordination in schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China. Electronic address:
Social functioning impairment is a core symptom of schizophrenia (SCZ). Yet, the computational and neural mechanisms of social coordination in SCZ under real-time and naturalistic settings are poorly understood. Here, we instructed patients with SCZ to coordinate with a healthy control (HC) in a joint finger-tapping task, during which their brain activity was measured by functional near-infrared spectroscopy simultaneously.
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