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Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers.
Clin Neuropsychol
January 2025
Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Exposure to repetitive head impacts (RHI), such as those experienced in American football, is linked to cognitive dysfunction later in life. Traumatic encephalopathy syndrome (TES) is a proposed clinical syndrome thought to be linked to neuropath-ology of chronic traumatic encephalopathy (CTE), a condition associated with RHI from football. Cognitive intra-individual variability (d-CIIV) measures test-score dispersion, indicating cognitive dysfunction.
View Article and Find Full Text PDFGrasping Post-Traumatic Stress Disorder (PTSD) from the Perspective of Psychoneuroimmunoendocrinology (PNIE): Etiopathogenic Mechanisms and Relevance for the Integrative Management.
Biol Psychiatry
January 2025
Department of Medicine and Medical Specialities, CIBEREHD, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain. Electronic address:
Post-Traumatic Stress Disorder (PTSD) is a debilitating condition caused by exposure to traumatic events, affecting 5-10% of the population, with increased prevalence among women and individuals in war zones. Beyond psychological symptoms, PTSD induces significant physiological changes across systems. Psychoneuroimmunoendocrinology (PNIE) offers a framework to explore these complex interactions between the psyche and the nervous, immune, and endocrine systems.
View Article and Find Full Text PDFPharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy.
Pharmaceuticals (Basel)
January 2025
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
The complexity of our life experiences and the rapid progress in science and technology clearly necessitate reflections from the humanities. The ever-growing intersection between science and society fosters the emergence of novel interdisciplinary fields of research. During the past decade, Medical Humanities arose to meet the need to unravel hidden information beyond technology-driven and fact-based medicine.
View Article and Find Full Text PDFBackground: With the increasing availability and use of digital tools such as virtual reality in medical education, there is a need to evaluate their impact on clinical performance and decision-making among healthcare professionals. The Trauma SimVR study is investigating the efficacy of virtual reality training in the context of traumatic in-hospital cardiac arrest.
Methods And Analysis: This study protocol (clinicaltrials.
Single- versus two-test criteria for cognitive impairment: associations with CSF and imaging markers in former American football players.
Clin Neuropsychol
January 2025
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Cognitive impairment is a core feature of traumatic encephalopathy syndrome (TES), the putative clinical syndrome of chronic traumatic encephalopathy-a neuropathological disease associated with repetitive head impacts (RHI). Careful operationalization of cognitive impairment is essential to improving the diagnostic specificity and accuracy of TES criteria. We compared single- versus two-test criteria for cognitive impairment in their associations with CSF and imaging biomarkers in male former American football players.
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