Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Safety and Efficacy of Jenacid® Herbal Product Against Indomethacin-Induced Ulcers in Albino Wistar Rats.
Cureus
October 2024
Department of Pharmacology and Toxicology, Kampala International University Western Campus, Bushenyi, UGA.
Background: Jenacid Herbal Product (JHP) used for treating peptic ulcer disease in Uganda, sold over the counter, is approved by the National Drug Authority as a Traditional Herbal Product number THP 482. There have been no published studies on its safety and efficacy.
Objective: This study aimed to assess potential acute and subacute toxicity as well as the efficacy of JHP.
Tadalafil pretreatment attenuates doxorubicin-induced hepatorenal toxicity by modulating oxidative stress and inflammation in Wistar rats.
Toxicol Rep
December 2024
Department of Oral Pathology and Medicine, Faculty of Dentistry, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria.
Doxorubicin (DOX) is a widely used anticancer agent, but its clinical application is limited by significant off-target hepatorenal toxicity. Tadalafil (TAD), a selective phosphodiesterase-5 inhibitor used mainly for erectile dysfunction and pulmonary arterial hypertension, has shown potential in reducing oxidative stress. This study investigated TAD's chemoprotective effects and underlying mechanisms in DOX-induced hepatorenal toxicity in rats over 12 days.
View Article and Find Full Text PDFIn vivo cardiovascular profile of ryanodine receptor 2 inhibitor M201-A: Utility as an anti-atrial fibrillatory drug for patients suffering from heart failure with preserved ejection fraction.
J Pharmacol Sci
November 2024
Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Kazuya Yokoyama Cancer Research Institute, 1-4-8 Ueno, Taito-ku, Tokyo, 110-0005, Japan. Electronic address:
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) often coexist; however, clinically available anti-AF drugs can exacerbate symptoms of HFpEF. M201-A suppressed ryanodine receptor-mediated diastolic Ca leakage, possibly inhibiting common pathological processes toward AF and HFpEF. To bridge the basic information to clinical practice, we assessed its cardiohemodynamic, anti-AF and ventricular proarrhythmic profile using halothane-anesthetized dogs (n = 4).
View Article and Find Full Text PDFAnalysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs.
J Toxicol Sci
June 2024
Department of Pharmacology, Faculty of Medicine, Toho University.
Although morphine has been used for treatment-resistant dyspnea in end-stage heart failure patients, information on its cardiovascular safety profile remains limited. Morphine was intravenously administered to halothane-anesthetized dogs (n=4) in doses of 0.1, 1 and 10 mg/kg/10 min with 20 min of observation period.
View Article and Find Full Text PDFHepatoprotective effect of methanol fruit extract of L in highly active antiretroviral therapy-induced toxicity in Wistar rats.
Drug Chem Toxicol
March 2024
Department of Science Technical and Vocational Education, Makerere University, Kampala, Uganda.
Article Synopsis
- Prolonged use of Highly Active Antiretroviral Therapy (HAART) can cause liver toxicity, with limited treatment options for hepatic cell regeneration.
- A study assessed the protective effects of Methanol fruit extract (MFEPG) on rats undergoing HAART, revealing that MFEPG helped restore normal liver function and reduced oxidative damage indicators.
- The findings suggest that MFEPG has antioxidant properties capable of mitigating HAART-induced liver injury, but further research is necessary to confirm its safety and efficacy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!