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Acute macular neuroretinopathy occurrence in a Behçet disease patient: a case report.
J Ophthalmic Inflamm Infect
January 2025
Ophthalmology Department, CHIREC Braine-l'Alleud-Waterloo Hospital, Braine l'Alleud, Belgium.
Purpose: To report the occurrence of AMN (Acute Macular Neuroretinopathy) in a Behçet Disease (BD) patient during an active systemic inflammatory relapse and to describe the SD-OCT features of this entity.
Patients And Methods: Retrospective observational case report of a patient who presented with an AMN during a BD associated ocular inflammation (Saint Pierre Hospital, Brussels, Belgium). Clinical record and imaging, including infrared reflectance image (IR) and spectral domain optical coherence tomography (SD-OCT), were analyzed.
Disseminated protothecosis caused by Prototheca bovis in two dogs.
J Comp Pathol
December 2024
Departamento de Ciências Veterinárias, Universidade Federal do Paraná, Setor Palotina, Rua Pioneiro, 2153, Palotina, Paraná, 85950-000, Brazil.
Protothecosis is an infectious disease caused by unicellular algae of the genus Prototheca, which are mainly known for causing mastitis in farm animals. However, there are reports of protothecosis in humans and other animals, such as dogs and cats, which develop cutaneous lesions or systemic lesions. Dogs with the systemic form generally develop bloody diarrhoea and blindness and neurological signs may also occur.
View Article and Find Full Text PDFOcular manifestations of West Nile virus infection: A case report and systematic review of the literature.
Eur J Ophthalmol
December 2024
Division of Ocular Immunology, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Article Synopsis
- * Out of 60 patients reviewed, most were middle-aged males from the U.S., with a significant proportion experiencing neurological issues and diabetes as a common health factor.
- * Key eye symptoms included multifocal chorioretinal lesions and inflammation, with many eyes not receiving treatment; the study highlights the importance of considering WNVI in older patients showing eye issues after recent flu-like symptoms.
Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection.
Sci Adv
November 2024
Department of Microbiology and Immunology, Jefferson Center for Vaccines and Pandemic Preparedness, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Human cytomegalovirus (CMV) causes a common congenital infection leading to long-term neurological impairments including brain, cochlear, and ocular pathology. Infection of newborn mice with murine (M)CMV is an established model of neuropathology caused by congenital CMV infection, with recent work suggesting that brain pathology may be driven by immune responses. In the eye, however, CMV retinitis is thought to result from virus-driven necrosis in the absence of T cell responses.
View Article and Find Full Text PDFArticle Synopsis
- Gaucher disease type 3 is a genetic disorder caused by a deficiency in the enzyme β-glucocerebrosidase, leading to a variety of health issues, particularly affecting the cardiac, neurological, and eye systems, with symptoms typically appearing before age 18.
- Type 3c, a specific form of this disease, is linked to a genetic variant and is unique for its association with heart problems, although few cases have been documented, making its full range of symptoms unclear.
- The case of a 20-year-old female with an unusual presentation of type 3c that includes eye inflammation and nerve damage—yet normal heart function—highlights the diverse manifestations of the disease and the need for better guidelines in evaluating
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