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A 51-year-old man with a history of antibiotic therapy for syphilis 1 month ago presented with syncope. Computed tomography revealed circumferential aortic wall thickening complicating severe stenosis of left main coronary ostium. Abnormalities in serologic and cerebrospinal fluid tests led to the diagnosis of syphilitic aortitis and neurosyphilis.

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Multiple liver metastases of unknown origin: A case report.

World J Gastrointest Oncol

January 2025

Department of Hepatobiliary Pancreatic Surgery, Peking University First Hospital, Beijing 100034, China.

Background: The liver is the most common site of digestive system tumor metastasis, but not all liver metastases can be traced back to the primary lesions. Although it is unusual, syphilis can impact the liver, manifesting as syphilitic hepatitis with inflammatory nodules, which might be misdiagnosed as metastasis.

Case Summary: This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three months.

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Optical Coherence Tomography Angiography findings in Syphilitic Outer Retinitis.

Retin Cases Brief Rep

December 2024

Department of Ophthalmology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.

Purpose: to report optical coherence tomography angiography findings in syphilitic outer retinopathy, a singular clinical manifestation of ocular syphilis.

Methods: case report.

Results: Multimodal imaging including optical coherence tomography angiography was performed in a patient presenting syphilitic outer retinopathy.

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A case of neuron-derived neurotrophic factor-positive, syphilis-related membranous nephropathy that achieved spontaneous remission.

CEN Case Rep

December 2024

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Neuron-derived neurotrophic factor (NDNF) was discovered as a target antigen in membranous nephropathy (MN) caused by syphilis. However, there have been few reports of NDNF-positive MN in Japan. A 19-year-old female patient was admitted to our hospital with nephrotic syndrome and acute kidney injury.

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Syphilitic Hepatitis: An Uncommon Manifestation of Secondary Syphilis.

Cureus

November 2024

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA) Health, Los Angeles, USA.

Syphilitic hepatitis is a rare manifestation of a sexually transmitted infection. Given its nonspecific presentation, it is important for clinicians to consider the diagnosis in sexually active patients presenting with elevated liver tests.  In this case, a 30-year-old man presented with an itchy rash and was diagnosed with an allergic reaction.

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