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Methionine-producing tumor micro(be) environment fuels growth of solid tumors.
Cell Oncol (Dordr)
December 2023
Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
Background: Recent studies have uncovered the near-ubiquitous presence of microbes in solid tumors of diverse origins. Previous literature has shown the impact of specific bacterial species on the progression of cancer. We propose that local microbial dysbiosis enables certain cancer phenotypes through provisioning of essential metabolites directly to tumor cells.
View Article and Find Full Text PDFAdsorption of the Tartrate Ions in the Hydroxyapatite/Aqueous Solution of NaCl System.
Materials (Basel)
June 2021
Department of Radiochemistry and Environmental Chemistry, Faculty of Chemistry, Maria Curie-Skłodowska University, 3 Maria Curie-Skłodowska Square, 20-031 Lublin, Poland.
The research on the interaction of tartrate ions with the surface of hydroskyapatite was presented, including the measurements of the kinetics of tartrate ion adsorption and tartrate ion adsorption as a function of pH. The adsorption of tartrate ions was calculated from the loss of tartrate concentration in the solution as measured by a radioisotope method using C-14 labeled tartaric acid. In order to explain the mechanism of interaction of tartrate ions with hydroxyapatite, supplementary measurements were carried out, i.
View Article and Find Full Text PDFSynthesis of [H-3]- and [C-14]-labeled elagolix.
J Labelled Comp Radiopharm
June 2021
Department of Process Chemistry, Radiochemistry, AbbVie Inc., North Chicago, Illinois, USA.
Gonadotropin-releasing hormone (GnRH) receptor antagonists are an important class of compounds designed to block the pituitary gland from synthesizing follicle-stimulating hormone and luteinizing hormone for the treatment of sex hormone dependent disorders. Elagolix (ABT-620) is currently approved for the treatment of pain associated with endometriosis and as a combination with estradiol and norethindrone acetate is approved for management of heavy menstrual bleeding due to uterine fibroids. In order to support the development of elagolix, we prepared [ H]elagolix for preclinical metabolism studies and [ C]elagolix for environmental risk assessment studies.
View Article and Find Full Text PDFSynthesis of C-14 labeled Rac-(3R,2S)-glycopyrronium bromide.
J Labelled Comp Radiopharm
August 2020
Pharmaceutical Sciences, R&D AstraZeneca, Gothenberg, Sweden.
In an effort to better understand the drug metabolism and pharmacokinetics (DMPK) properties of glycopyrronium bromide (1), a muscarinic acetylcholine receptor antagonist, a C-14 labeled isotopologue was required. The compound was prepared in five synthetic steps and 5% overall radiochemical yield from Cu CN. During the synthesis, an unexpected decarboxylation of phenylglyoxylate resulted in the loss of much of the radiolabeled compound.
View Article and Find Full Text PDFRequirement for the intestinal epithelial insulin-like growth factor-1 receptor in the intestinal responses to glucagon-like peptide-2 and dietary fat.
FASEB J
May 2020
Department of Physiology, University of Toronto, Toronto, ON, Canada.
The intestinal hormone, glucagon-like peptide-2 (GLP-2), enhances the enterocyte chylomicron production. However, GLP-2 is known to require the intestinal-epithelial insulin-like growth factor-1 receptor (IE-IGF-1R) for its other actions to increase intestinal growth and barrier function. The role of the IE-IGF-1R in enterocyte lipid handling was thus tested in the GLP-2 signaling pathway, as well as in response to a Western diet (WD).
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