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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy.
Drug Des Devel Ther
January 2025
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Purpose: This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy.
Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult rats and simulated by oxygen-glucose deprivation (OGD) in BV-2 microglial cells. Neurological and sensorimotor function, cerebral infarct volume, histopathological changes, mitochondrial morphological changes, and apoptosis of ischemic brain tissues were assessed in the presence or absence of esketamine and the autophagy inducer rapamycin.
Comparative ovarian morphophysiology of rats and Zebrafish after exposure to nandrolone decanoate.
Anim Reprod
January 2025
Programa de Pós-graduação em Biotecnologia - PPGBiotec, Universidade Federal do Delta do Parnaíba - UFDPar, Parnaíba, PI, Brasil.
This study aimed to compare the effects of nandrolone decanoate on the morphology and physiology of ovarian tissues in two experimental models, Zebrafish and rats, after in vitro cultivation. A total of 136 animals were used ( rats, n=36, and Zebrafish, n=100). In both experiments, the animals were divided into two groups (Control and Deca) and were exposed to nandrolone decanoate for seven weeks.
View Article and Find Full Text PDFAggressive Behavior of Recurrent Middle Cerebral Artery Aneurysms: A Case Series.
Cureus
December 2024
Vascular Neurosurgery, National Institute of Neurology and Neurosurgery, Mexico City, MEX.
The bifurcation of the middle cerebral artery (MCA) is one of the most common sites for the formation of cerebral aneurysms, presenting significant challenges for surgical management. A primary concern in this area is the recurrence of aneurysms following surgical clipping, which necessitates a thorough investigation of the contributing factors. This study examined all cases of rebleeding from previously clipped MCA aneurysms among 195 surgically treated patients over an 11-year period.
View Article and Find Full Text PDFMUSCULOSKELETAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS.
Acta Clin Croat
December 2023
Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that most commonly affects the young, working, female population. Musculoskeletal manifestations are one of the most prevalent and presenting features in SLE. Arthralgia, myalgia, non-erosive arthritis, myositis but also tenosynovitis and enthesitis are present in more than 90% of SLE patients.
View Article and Find Full Text PDFAn ictogenic marker in the mesial temporal epilepsy and its temporal evolutionary features.
Front Neurol
January 2025
Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Objective: To observe and measure the morphological and temporal evolutionary features of the hypersynchronous (HYP) pattern in the mesial temporal seizure.
Methods: The HYP patterns during preictal and interictal states of 16 mesial temporal epileptic patients were analyzed. The wave components of the HYP transients were firstly observed and measured.
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