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Clinico-physiological correlates of Parkinson's disease from multi-resolution basal ganglia recordings.
NPJ Parkinsons Dis
September 2024
Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Parkinson's disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms.
View Article and Find Full Text PDFHypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.
Sci Total Environ
February 2024
Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi 110007, India; Institute of Hypoxia Research, New Delhi 110067, India. Electronic address:
Genetic variants play a crucial role in shaping the adaptive phenotypes associated with high-altitude populations. Nevertheless, a comprehensive understanding of the specific impacts of different environments associated with increasing altitudes on the natural selection of these genetic variants remains undetermined. Hence, this study aimed to identify genetic markers responsible for high-altitude adaptation with specific reference to different altitudes, majorly focussing on an altitude elevation range of ∼1500 m and a corresponding decrease of ≥5 % in ambient oxygen availability.
View Article and Find Full Text PDF[Clinico-physiological parameters of diabetic polyneuropathy in elderly patients with diabetes mellitus type II and the treatment].
Adv Gerontol
July 2018
I. I. Mechnikov North-Western State Medical University, St. Petersburg, 193015, Russian Federation;
Changes of subjective and objective symptoms, elektroneyromiographic parameters, analysis of vegetative system were perfomed in 120 patients with diabetes mellitus type 2. The obtained results show the dependence of subjective and objective manifestations from the duration of the disease.
View Article and Find Full Text PDF[Acute onset pulmonary toxicity associated to amiodarone].
Acta Med Port
December 2013
Serviço de Pneumologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Amiodarone is a potent anti-arrhythmic drug with a well-known potential chronic pulmonary toxicity. We describe a case of acute pulmonary toxicity (APT) induced by amiodarone in a 57 year old patient submitted to a perfusion of 900 mg in just 6 hours, to control an auricular flutter with rapid ventricular response. During the administration, the patient developed hemodynamic instability and oxygen dessaturation that led to an electrical cardioversion with return of sinus rhythm.
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