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Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease.
TH Open
October 2024
Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Association between global platelet function and the risk of venous thromboembolic disease (VTE) has been proposed, though the mechanisms do not involve increased platelet aggregation. However, platelet adhesiveness has not been systematically explored in VTE patients. To evaluate platelet adhesive functions in VTE patients.
View Article and Find Full Text PDFHeparin Immobilization Enhances Hemocompatibility, Re-Endothelization, and Angiogenesis of Decellularized Liver Scaffolds.
Int J Mol Sci
November 2024
College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Article Synopsis
- Bioengineered livers are being studied as alternatives to traditional liver transplants, addressing donor shortages, but they face issues like thrombosis due to incomplete endothelial layers.
- This study focuses on applying heparin to decellularized liver scaffolds to improve blood compatibility, cell adhesion, and new blood vessel formation.
- Results showed that heparin not only reduced blood clotting and increased cell attachment but also significantly enhanced the growth of blood vessels in the scaffolds when tested in mice.
Effect of In Vitro Low-Impulse Laser Irradiation on Morphofunctional Properties of Human Platelets.
Bull Exp Biol Med
November 2024
Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia.
We studied morphofunctional features of human platelets exposed in vitro to low-pulse laser radiation (LPLR) with different wavelengths. Platelet-rich plasma (PRP) was irradiated at wavelengths of 635, 488, and 355 nm. LPLR with λ=635 nm and 1 W power after 10 min caused degranulation of many platelets, formation of small platelet conglomerates, and accelerated platelet adhesion on glass.
View Article and Find Full Text PDFShore hardness of bulk polyurethane affects the properties of nanofibrous materials differently.
J Mech Behav Biomed Mater
January 2025
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland. Electronic address:
The present study shows the effect of the hardness of bulk polyurethane on the properties of nanofibrous materials produced in the solution blow spinning process. This study focuses on nanofibrous materials made from medical-grade polyurethanes with different hardness values on the Shore scale, from 75A to 75D. We aimed to determine the effect of the intrinsic properties of polyurethane used to produce nanofibers on the tensile properties of the resulting nanofibrous materials and in vitro platelet adhesiveness.
View Article and Find Full Text PDFPlatelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates.
Thromb Res
December 2024
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands. Electronic address:
Article Synopsis
- This study analyzes how different platelet collagen receptors (GPVI, α2β1, and GPIb-IX-V) interact with various sources of collagen, impacting platelet activation and thrombus formation.
- Ethical collagens tested include type I collagen from equine tendon, rat tail, and acid-soluble collagen from human umbilical cord.
- The results show varied reliance on receptors for platelet aggregation depending on the collagen type, with GPVI playing a crucial role in reducing thrombus parameters when inhibited, demonstrating that collective receptor interactions influence platelet behavior on different collagen surfaces.
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