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Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease.
Rheumatol Ther
January 2025
LBAI, UMR1227, Univ Brest, Inserm, Brest, France.
Introduction: Celiac disease (CD) affects the small intestine, leading to a progressive disappearance of intestinal villi, and can be found in association with several other autoimmune and inflammatory conditions. The main objective of this study was to determine the prevalence and the clinical significance of anti-transglutaminase and anti-endomysium antibodies in patients diagnosed with early rheumatoid arthritis (RA) and spondyloarthritis (SpA).
Methods: We measured anti-transglutaminase and anti-endomysium antibodies in biobanked serum samples at inclusion in two French prospective multicenter cohorts of patients with suspected early rheumatoid arthritis (ESPOIR, n = 713) and spondyloarthritis (DESIR, n = 709).
Celiac Crisis: A Life-Threatening Complication of Celiac Disease.
Middle East J Dig Dis
October 2024
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India.
Celiac disease (CD) is an immune-mediated enteropathy with varied systemic involvement and association with increased morbidity and mortality. Strong clinical suspicion is the key, and diagnosis is made using histopathology and serology. Though the consumption of a strict gluten-free diet can improve symptoms and limit mucosal damage, curative therapy is still lacking.
View Article and Find Full Text PDFCeliac Disease in Children and YouTube: Do the Videos Contain Accurate Information?
Turk Arch Pediatr
January 2025
Division of Pediatric Gastroenterology, Department of Pediatrics, Hepatology and Nutrition, Süleyman Demirel University School of Medicine, Isparta, Türkiye.
Objective: Celiac disease (CD) is a gluten-associated enteropathy whose incidence has been increasing in recent years. Parents whose children are diagnosed with CD search for information about the disease via the internet. YouTube is one of the most frequently used platforms to access information due to the number of users and ease of access.
View Article and Find Full Text PDFThink With Your Gut: A Retrospective Analysis on the Effects of Chronic Gastrointestinal Illness and Psychiatric Comorbidities.
Gastroenterology Res
December 2024
Department of Internal Medicine, HCA Healthcare; MountainView Hospital, Las Vegas, NV, USA.
Background: As mental health awareness increases, healthcare professionals must understand the interplay between chronic gastrointestinal (GI) conditions and psychological well-being, particularly regarding healthcare utilization. This study uniquely aggregates various chronic GI disorders, such as inflammatory bowel disease, celiac disease, and eosinophilic esophagitis, to examine their impact on depression and anxiety.
Methods: Utilizing a retrospective observational design, we analyzed data from 34,876 patients admitted to HCA national hospitals from January 2016 to December 2022.
Activated CD27PD-1 CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II.
Gastro Hep Adv
September 2024
Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Background And Aims: Refractory celiac disease type II (RCDII) is characterized by a clonally expanded aberrant cell population in the small intestine. The role of other tissue-resident immune subsets in RCDII is unknown. Here, we characterized CD8 and CD4 T cells in RCDII duodenum at the single-cell level and .
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