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A Case of Diffuse Sclerosing Osteomyelitis (DSO) Initially Diagnosed as Bacterial Mandibular Osteomyelitis and Successfully Treated With Bisphosphonate Administration (Ibandronate).
Cureus
December 2024
Department of Oral and Maxillofacial Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JPN.
Diffuse sclerosing osteomyelitis (DSO) is a non-bacterial disease of the jawbone, characterized by intermittent pain, swelling, and a mixture of osteosclerosis and osteolysis on radiographs. Its etiology remains unclear, and a standard treatment, based on clear diagnostic criteria, has not been established. We present the case of a 48-year-old male patient, who was initially diagnosed with chronic mandibular osteomyelitis due to apical periodontitis in the right lower second premolar, and underwent antimicrobial medication and surgical therapy based on computed tomography (CT), magnetic resonance imaging (MRI), and bone scintigraphy.
View Article and Find Full Text PDFChronic recurrent multifocal osteomyelitis in pediatric patients: A Chinese single center observational study and literature review.
Medicine (Baltimore)
December 2024
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disorder that commonly poses diagnostic challenges due to its atypical symptomatology. This observational study aimed to investigate the clinical features, laboratory test results, imaging features, and treatment strategies for pediatric patients with CRMO. We retrospectively analyzed 7 pediatric patients with CRMO treated at the Department of Pediatric Orthopedics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between January 2018 and February 2022.
View Article and Find Full Text PDFPacritinib prevents inflammation-driven myelofibrosis-like phenotype in a miR-146a murine model.
Biomed Pharmacother
December 2024
Hematology Department, Hospital Universitario Morales-Meseguer, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, Murcia, Spain; CIBERER-ISCIII CB15/00055 (U765), Spain; Universidad de Murcia, Murcia, Spain; Universidad Católica San Antonio (UCAM), Murcia, Spain. Electronic address:
Chronic proinflammatory signaling is a characteristic trait in myeloproliferative neoplasms (MPN), particularly myelofibrosis (MF). Aberrant inflammatory signaling, particularly from NF-κB pathway, exacerbates the progression of MPN. Previously, we identified a critical role of miR-146a, a negative regulator of the TLR/NF-κB axis, in MF development.
View Article and Find Full Text PDFSurgical treatment of progressive melorheostosis worsening over 19 years: A case report.
Knee
December 2024
Department of Orthopedics, Peking University Third Hospital, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Beijing, China. Electronic address:
Article Synopsis
- * A patient with melorheostosis had affected bones in the left acetabulum, femur, tibia, and talus, which progressed slowly over 19 years and restricted knee motion.
- * Effective management involved physical therapy, medications, and surgeries, successfully improving range of motion without recurrence for two years following the removal of excess calcified mass.
A rare case of Erdheim Chester disease.
Radiol Case Rep
December 2024
Central Unit of Radiology, University Hospital Center Ibn Rochd, School of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.
Article Synopsis
- Erdheim-Chester disease (ECD) is a rare condition classified as non-Langerhans cell histiocytosis, with limited cases documented in literature.
- A 53-year-old patient exhibited symptoms including xanthelasma (skin lesions), extreme fatigue, loss of appetite, and chronic breathing difficulties over five years.
- Imaging scans revealed significant signs of ECD, and a biopsy solidified the diagnosis, emphasizing the need for radiologists to recognize ECD signs to prevent misdiagnosis.
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