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Molecular regulatory effect of the ergot alkaloid methylergometrine on the α3β4 nicotinic acetylcholine receptor.
Biochem Biophys Res Commun
December 2024
Department of Biotechnology and Department of Integrative Food, Bioscience and Biotechnology (BK21 FOUR), Chonnam National University, Gwangju, 61186, South Korea. Electronic address:
Methylergometrine has widely been used pharmacologically to treat conditions such as pain, addiction, vasoconstriction, migraines, and Parkinson's disease. Despite its side effects, it is used as a therapeutic agent and research material for various diseases based on its natural potential; however, the regulatory effect of its interaction with the nicotinic acetylcholine receptor (nAChR) has not yet been investigated. The α3β4 nAChR is an ion channel essential for neurotransmission within the sympathetic, parasympathetic, and autonomic nervous systems.
View Article and Find Full Text PDFFeed-induced hypersalivation in horses from Austria, Germany and Switzerland.
Equine Vet J
November 2024
Lehrstuhl für Tierernährung und Diätetik, Ludwig-Maximilians-Universität München, Munich, Germany.
Background: While previous reports come mostly from the southern Americas, several outbreaks of hypersalivation in horses were observed in Middle Europe from 2016 to 2018.
Objective: To describe feed-induced hypersalivation in European horses.
Study Design: Analysis of feedstuffs.
Polysubstituted Pyridines from 1,4-Oxazinone Precursors.
J Org Chem
December 2024
Department of Chemistry, William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187, United States.
This study describes a general method for the preparation of 1,4-oxazin-2-one intermediates from acetylene dicarboxylate and β-amino alcohol precursors. Oxazinones prepared in this manner were employed in a tandem cycloaddition/cycloreversion reaction sequence with a model alkyne (phenyl acetylene) to give substituted pyridine products. Fundamental reactivity and selectivity studies are complemented by the synthesis of the polycyclic ergot alkaloid natural product xylanigripone A.
View Article and Find Full Text PDFFirst report of ergot caused by in switchgrass ( L.) in Georgia, USA.
Plant Dis
October 2024
University of Georgia, Plant Pathology, Griffin, Georgia, United States.
Switchgrass (Panicum virgatum L.) is a North American grass species with biofuel potential. Claviceps spp.
View Article and Find Full Text PDFThe control of ergot alkaloids in biotechnological processes is important in the context of obtaining new strain producers and studying the mechanisms of the biosynthesis, accumulation and secretion of alkaloids and the manufacturing of alkaloids. In pharmaceuticals, it is important to analyze the purity of raw materials, especially those capable of racemization, quality control of dosage forms and bulk drugs, stability during storage, etc. This review describes the methods used for qualitative and quantitative chemical analysis of ergot alkaloids in tablets and pharmaceutic forms, liquid cultural media and mycelia from submerged cultures of ergot and other organisms producing ergoalkaloid, sclerotias of industrial .
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