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INTERACTION OF SMALL HEAT SHOCK PROTEINS WITH BAG3.
Biochimie
January 2025
Department of Biochemistry, School of Biology, M.V. Lomonosov Moscow State University; Department of Biochemistry and Regenerative Biomedicine Faculty of Basic Medicine, M.V. Lomonosov Moscow State University. Electronic address:
BAG3 is a universal adapter protein involved in various cellular processes, including the regulation of apoptosis, chaperone-assisted selective autophagy, and heat shock protein function. The interaction between small heat shock proteins (sHsps) and their α-crystallin domains (Acds) with full-length BAG3 protein and its IPV domain was analyzed using size-exclusion chromatography, native gel electrophoresis, and chemical cross-linking. HspB7 and the 3D mutant of HspB1 (which mimics phosphorylation) showed no interaction, HspB6 weakly interacted, and HspB8 strongly interacted with full-length BAG3.
View Article and Find Full Text PDFHypergammaglobulinemia in Hidradenitis Suppurativa Patients: A New Emerging Association.
Clin Cosmet Investig Dermatol
January 2025
Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Hypergammaglobulinemia is a sign of B cell and plasma cell hyperactivity marked by elevated levels of gamma globulins, proteins within the gamma fraction of serum electrophoresis, linked to diseases like acute hepatitis, Hodgkin's lymphoma, autoimmune conditions, and neoplasms. Monoclonal gammopathy of undetermined significance (MGUS) is found in 3.2% of individuals over 50 and 5.
View Article and Find Full Text PDFNanoscale Characterization of Interaction of Nucleosomes with H1 Linker Histone.
Int J Mol Sci
December 2024
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198-6025, USA.
In eukaryotic nuclei, DNA is wrapped around an octamer of core histones to form nucleosomes. H1 binds to the linker DNA of nucleosome to form the chromatosome, the next structural unit of chromatin. Structural features on individual chromatosomes contribute to chromatin structure, but not fully characterized.
View Article and Find Full Text PDFComparative Proteomics of Resistant and Susceptible Strains of Frankliniella occidentalis to Abamectin.
Electrophoresis
January 2025
Department of Cell & Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Western flower thrips, Frankliniella occidentalis (Thysanoptera: Thripidae) is an invasive agricultural pest with developed resistance to abamectin in some strains due to frequent treatment with the pesticide. In this study, we examined differentially expressed proteins (DEPs) between abamectin-resistant (Aba; under abamectin selective pressure) and susceptible strains (Aba; without abamectin selective pressure) of F. occidentalis.
View Article and Find Full Text PDFPrevalence of ApoE Alleles in a Spanish Population of Patients with a Clinical Diagnosis of Alzheimer's Disease: An Observational Case-Control Study.
Medicina (Kaunas)
November 2024
Health Research Nursing Group (GREIS), University of Leon, 24071 Leon, Spain.
: Alzheimer's dementia is a progressive neurodegenerative disease that affects memory abilities due to genetic and environmental factors. A well-known gene that influences the risk of Alzheimer's disease is the apolipoprotein E (APOE) gene. The APOE gene is involved in the production of a protein that helps transport cholesterol and other types of fat in the bloodstream.
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