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[Kocher and goitre].
Ned Tijdschr Geneeskd
September 2012
Nederlands Tijdschrift voor Geneeskunde, Amsterdam, the Netherlands.
Emile Theodor Kocher (1841-1917) studied and spent his entire career as surgeon (since 1866) and professor (since 1872) in his native Berne, apart from a 'grand tour' of surgical institutions in Europe. The discipline of surgery rapidly expanded, not least through the introduction of anaesthesia and antisepsis. Kocher's expertise ranged from ankle fractures to hypophysectomy; he wrote an authoritative textbook on surgical technique.
View Article and Find Full Text PDFDiabetes insipidus associated with propofol anesthesia.
J Clin Anesth
September 2008
Department of Anesthesiology, University of Washington Medical Center, Seattle, WA 98195, USA.
Diabetes insipidus is a clinical entity that is often seen in neurosurgical patients either during or immediately after transsphenoidal hypophysectomy. Rarely, diabetes insipidus can manifest as a new entity months later in patients who have previously had an intracranial injury or operation.
View Article and Find Full Text PDF[Intrasellar small TSH secreting pituitary adenomas, 2 case reports].
No Shinkei Geka
July 2007
Department of Neurosurgery, Kohnan Hospital, Sendai, Miyagi, Japan.
Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma accounts for 1% of pituitary adenoma and often manifests as invasive macroadenoma. If the TSH value is not high enough to cause clinical symptoms presenting as inappropriate secretion of TSH, the tumor may be missed or misdiagnosed as Graves disease. Some of these patients receive inadequate treatment with the antithyroid agent, radioiodine treatment, and thyroidectomy.
View Article and Find Full Text PDFActivation of the hepatic LDL receptor promoter by thyroid hormone.
Biochim Biophys Acta
September 2007
Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
The question of whether mature sterol regulatory element binding protein-2 (SREBP-2) mediates transcriptional activation of the hepatic low density lipoprotein (LDL) receptor by thyroid hormone was investigated. Western blotting analysis and electrophoretic mobility shift assays demonstrated that mature nuclear SREBP-2 protein could be detected in liver nuclear extracts prepared from normal animals but not in extracts prepared from rats rendered hypothyroid either by hypophysectomy (Hx) or thyroidectomy (Tx). Treatment of Hx rats with T3 restored LDL receptor mRNA levels in about 1 h and caused a 6-fold increase 2.
View Article and Find Full Text PDFRegulation of galanin-like peptide gene expression by pituitary hormones and their downstream targets.
J Neuroendocrinol
January 2004
Graduate Program in Neurobiology and Behaviour, University of Washington, Seattle, WA 98195-7290, USA.
Galanin-like peptide (GALP) mRNA is expressed in neurones of the hypothalamic arcuate nucleus and within pituicytes in the neurohypophysis. Several neuropeptides that are expressed in the arcuate nucleus participate in the neuroendocrine regulation of pituitary hormone secretion. Our objective was to determine the extent to which GALP might be a target for regulation by pituitary hormones or their downstream targets in the rat.
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